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Impregnation of Ultrahigh-Molecular-Weight Polyethylene with Amoxicillin in Subcritical Freon R22 Media

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Abstract

The method of impregnation of ultrahigh-molecular-weight polyethylene (UHMWPE) with amoxicillin in subcritical Freon R22 media is developed. For the first time, the possibility of polymer impregnation with a polar substance (a standard antibiotic amoxicillin) in the absence of cosolvents is shown. Cosolvents increase the polarity of the medium and removal of them from the polymer matrix is usually a serious problem. Amoxicillin desorption curves from the impregnated UHMWPE samples are obtained by high-performance liquid chromatography (HPLC). Polymeric samples impregnated with amoxicillin are active against gram-positive and gram-negative microorganisms S. aureus, S. epidermidis, E. faecalis, B. subtilis, and E. coli, allowing them to be considered as real implant models for replacement of bone tissue.

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Authors and Affiliations

  1. Federal State Unitary Enterprise State Plant of Medicinal Drugs, Moscow, 111024, Russia

    D. Yu. Zalepugin, N. A. Tilkunova, I. V. Chernyshova & M. I. Vlasov

  2. National University of Science and Technology MISiS, Moscow, 119049, Russia

    A. V. Maksimkin, M. V. Kiselevsky, N. Yu. Anisimova & F. S. Senatov

  3. Blokhin Russian Cancer Research Center, Ministry of Health of the Russian Federation, Moscow, 115478, Russia

    M. V. Kiselevsky, N. Yu. Anisimova & T. S. Spirina

Authors
  1. D. Yu. Zalepugin
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  2. A. V. Maksimkin
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  3. M. V. Kiselevsky
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  4. N. A. Tilkunova
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  5. N. Yu. Anisimova
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  6. I. V. Chernyshova
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  8. F. S. Senatov
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  9. M. I. Vlasov
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Correspondence to D. Yu. Zalepugin.

Additional information

Original Russian Text © D.Yu. Zalepugin, A.V. Maksimkin, M.V. Kiselevsky, N.A. Tilkunova, N.Yu. Anisimova, I.V. Chernyshova, T.S. Spirina, F.S. Senatov, M.I. Vlasov, 2017, published in Sverkhkriticheskie Flyuidy. Teoriya i Praktika, 2017, Vol. 12, No. 1, pp. 4–14.

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Zalepugin, D.Y., Maksimkin, A.V., Kiselevsky, M.V. et al. Impregnation of Ultrahigh-Molecular-Weight Polyethylene with Amoxicillin in Subcritical Freon R22 Media. Russ. J. Phys. Chem. B 11, 1215–1222 (2017). https://doi.org/10.1134/S1990793117080152

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  • DOI: https://doi.org/10.1134/S1990793117080152

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