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Novel agonists of melatonin receptors as promising hypotensive and neuroprotective agents for therapy of glaucoma

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Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry Aims and scope Submit manuscript

Abstract

Melatonin is a pineal hormone that has a capacity to lower intraocular pressure; it exhibits neuroprotective and antioxidant properties that make it possible to use melatonin in the therapy of glaucoma. Melatonin analogs demonstrating affinity to melatonin receptors are promising candidates for application as antiglaucomatous agents. Chemical modification of the melatonin structure can increase efficiency, bioavailability, and selectivity of melatonin analogs. We have designed and synthesized a number of new 2-oxindole derivatives, the ligands of melatonin MT3 receptors; these analogs are characterized by the ability to lower intraocular pressure in normotensive rabbits and high antioxidant activity against hydroxyl radical and superoxide anion-radical. New ligands significantly exceeding melatonin in antioxidant activity can be also applicable for the development of therapeutic agents for treatment of oxidative stress. The maximal hypotensive effect of the analogs was comparable to and lasted longer than that of melatonin. Combination of these properties suggests potential used of the analyzed melatonin analogs in complex therapy of glaucoma.

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Authors and Affiliations

  1. Moscow Helmholtz Research Institute of Eye Diseases, ul. Sadovaya-Chernogryazskaya, 14/19, Moscow, 105062, Russia

    N. B. Chesnokova, O. V. Beznos & A. V. Grigoryev

  2. Chemical Faculty, Moscow State University, Moscow, 119991, Russia

    N. A. Lozinskaya, M. S. Volkova, E. V. Zaryanova & N. S. Zefirov

Authors
  1. N. B. Chesnokova
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  2. O. V. Beznos
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  3. N. A. Lozinskaya
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  4. M. S. Volkova
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  5. E. V. Zaryanova
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  6. N. S. Zefirov
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  7. A. V. Grigoryev
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Corresponding author

Correspondence to O. V. Beznos.

Additional information

Original Russian Text © N.B. Chesnokova, O.V. Beznos, N.A. Lozinskaya, M.S. Volkova, E.V. Zaryanova, N.S. Zefirov, A.V. Grigoryev, 2017, published in Biomeditsinskaya Khimiya.

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Chesnokova, N.B., Beznos, O.V., Lozinskaya, N.A. et al. Novel agonists of melatonin receptors as promising hypotensive and neuroprotective agents for therapy of glaucoma. Biochem. Moscow Suppl. Ser. B 11, 272–278 (2017). https://doi.org/10.1134/S1990750817030039

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  • DOI: https://doi.org/10.1134/S1990750817030039

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