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Lateral redistribution of transmembrane proteins and liquid-ordered domains in lipid membranes with inhomogeneous curvature

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Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology Aims and scope

Abstract

A number of processes in living cells are accompanied by significant changes of the geometric curvature of lipid membranes. In turn, heterogeneity of the lateral curvature can lead to spatial redistribution of membrane components, most important of which are transmembrane proteins and liquid-ordered lipid-protein domains. These components have a so-called hydrophobic mismatch: the length of the transmembrane domain of the protein, or the thickness of the bilayer of the domain differ from the thickness of the surrounding membrane. In this work we consider redistribution of membrane components with hydrophobic mismatch in membranes with non-uniform geometric curvature. Dependence of the components’ energy on the curvature is calculated in terms of theory of elasticity of liquid crystals adapted to lipid membranes. According to the calculations, transmembrane proteins prefer regions of the membrane with zero curvature. Liquid-ordered domains having a size of a few nm distribute mainly into regions of the membrane with small negative curvature appearing in the cell plasma membrane in the process of endocytosis. The distribution of domains of a large radius is determined by a decrease of their perimeter upon bending; these domains distribute into membrane regions with relatively large curvature.

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Authors and Affiliations

  1. Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences, Leninskii pr. 31/5, Moscow, 119071, Russia

    D. S. Osipenko, T. R. Galimzyanov & S. A. Akimov

  2. National University of Science and Technology “MISiS”, Leninskii pr. 4, Moscow, 119049, Russia

    T. R. Galimzyanov & S. A. Akimov

Authors
  1. D. S. Osipenko
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  2. T. R. Galimzyanov
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  3. S. A. Akimov
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Correspondence to S. A. Akimov.

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Original Russian Text © D.S. Osipenko, T.R. Galimzyanov, S.A. Akimov, 2016, published in Biologicheskie Membrany, 2016, Vol. 33, No. 3, pp. 176–186.

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Osipenko, D.S., Galimzyanov, T.R. & Akimov, S.A. Lateral redistribution of transmembrane proteins and liquid-ordered domains in lipid membranes with inhomogeneous curvature. Biochem. Moscow Suppl. Ser. A 10, 259–268 (2016). https://doi.org/10.1134/S1990747816030077

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  • DOI: https://doi.org/10.1134/S1990747816030077

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