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Neurochemical Mechanisms of Pathogenesis and Pharmacological Correction of Autism Spectrum Disorders: Current Concepts and Prospects

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Abstract—The presence of a significant and constantly growing global prevalence of autism spectrum disorders (ASD) coupled with the ongoing search for optimal drugs and treatments has aroused heightened interest in this disease. The modern medical literature contains many publications on the impairments in the functioning and interaction of neurotransmitter systems in ASD and methods for their pharmacological correction. It has been established that the serotonergic, glutamatergic, GABAergic, dopaminergic, cholinergic, and opiate systems of the brain may be involved in the pathogenesis of ASD along with disturbances in the metabolism of oxytocin, arginine-vasopressin, and melatonin. This review presents an analysis of the main changes in these systems in ASD, mechanisms of drug-induced effects, and directions for the ongoing search for relevant pathogenic targets and drugs.

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  1. Zakusov Institute of Pharmacology, ul. Baltiiskaya 8, 125315, Moscow, Russia

    A. A. Alymov, I. G. Kapitsa & T. A. Voronina

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Alymov, A.A., Kapitsa, I.G. & Voronina, T.A. Neurochemical Mechanisms of Pathogenesis and Pharmacological Correction of Autism Spectrum Disorders: Current Concepts and Prospects. Neurochem. J. 15, 129–138 (2021). https://doi.org/10.1134/S1819712421020033

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