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The effects of high-energy protons and carbon ions (12C) on the cognitive function and the content of monoamines and their metabolites in peripheral blood in monkeys

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Abstract

Model experiments using monkeys (rhesus macaque monkeys) were performed to investigate the neurobiological effects of two components of galactic cosmic radiation, namely, high-energy protons and carbon (12C) ions. It has been demonstrated that the irradiation of a monkey’s head with protons at a dose of 3 Gy did not cause any significant changes in the animal’s cognitive function and in the concentrations of monoamines and their metabolites in the peripheral blood. However, exposure to carbon ions at a dose of 1 Gy resulted in a significant cognitive function impairment and a significant decrease in serotonin metabolite concentrations in the blood in the monkeys with the excitable imbalanced type of higher nervous activity.

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Authors and Affiliations

  1. State Scientific Center of the Russian Federation, Institute for Medical and Scientific Problems, Russian Academy of Sciences, Moscow, Russia

    A. G. Belyaeva, A. S. Shtemberg, A. M. Nosovskii, O. N. Vasil’eva, Yu. V. Gordeev, V. S. Kudrin & A. S. Bazyan

  2. Institute for Higher Nervous Function and Neurophysiology, Russian Academy of Sciences, Moscow, Russia

    A. S. Bazyan

  3. Zakusov Institute of Pharmacology, Russian Academy of Sciences, Moscow, Russia

    V. S. Kudrin & V. B. Narkevich

  4. Joint Institute for Nuclear Research, Dubna, Moscow Region, Russia

    A. S. Shtemberg, E. A. Krasavin, G. N. Timoshenko & A. S. Bazyan

  5. Research Institute for Medical Primatology, Russian Academy of Sciences, Sochi, Russia

    B. A. Lapin

  6. ul. Butlerova 5a, 117485, Moscow, Russia

    A. S. Bazyan

Authors
  1. A. G. Belyaeva
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  2. A. S. Shtemberg
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  3. A. M. Nosovskii
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  4. O. N. Vasil’eva
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  5. Yu. V. Gordeev
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  6. V. S. Kudrin
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  7. V. B. Narkevich
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  8. E. A. Krasavin
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  9. G. N. Timoshenko
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  10. B. A. Lapin
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  11. A. S. Bazyan
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Corresponding author

Correspondence to A. S. Bazyan.

Additional information

Original Russian Text © A.G. Belyaeva, A.S. Shtemberg, A.M. Nosovskii, O.N. Vasil’eva, Yu.V. Gordeev, V.S. Kudrin, V.B. Narkevich, E.A. Krasavin, G.N. Timoshenko, B.A. Lapin, A.S. Bazyan, 2017, published in Neirokhimiya, 2017, Vol. 34, No. 2, pp. 168–176.

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Belyaeva, A.G., Shtemberg, A.S., Nosovskii, A.M. et al. The effects of high-energy protons and carbon ions (12C) on the cognitive function and the content of monoamines and their metabolites in peripheral blood in monkeys. Neurochem. J. 11, 168–175 (2017). https://doi.org/10.1134/S1819712417010032

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  • DOI: https://doi.org/10.1134/S1819712417010032

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