Abstract
The PBAF chromatin remodeling complex regulates chromatin state and gene transcription in higher eukaryotes. In this work, we studied the role of PBAF in the regulation of NF-κB-and JAK/STAT-dependent activation of inflammatory genes. We performed knockdown of specific module subunit BAF200, which resulted in destruction of the entire PBAF specific module and changed the level of the genes transcription of both pathways. PBAF can be both an activator and a repressor of inflammatory genes. Thus, PBAF is an important regulator of inflammatory gene expression.
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This work was supported by the Russian Foundation for Basic Research (project no. 21-14-00258).
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The authors declare that they have no conflicts of interest. This article does not contain any studies involving animals or human participants performed by any of the authors.
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Translated by M. Batrukova
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Feoktistov, A.V., Georgieva, S.G. & Soshnikova, N.V. Chromatin Remodeling Complex PBAF Activates and Represses Inflammatory Genes. Dokl Biochem Biophys 513, 332–336 (2023). https://doi.org/10.1134/S1607672923700539
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DOI: https://doi.org/10.1134/S1607672923700539