Abstract
Polymeric derivatives of proteins are synthesized by the reaction of the amino groups of proteins with N,N-diethylacrylamides containing terminal carboxyl groups, having a molecular weight of (13–62) × 103, and exhibiting a lower critical solution temperature of 34–29°C. It is shown for the first time that the lower critical solution temperature of the obtained derivatives is determined not only by the molecular weight of the polymer and protein but also by the conformation of the protein macromolecule.
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REFERENCES
L. I. Valuev, O. N. Zefirova, I. V. Obydennova, and N. A. Plate, Vysokomol. Soedin., Ser. A 35, 83 (1993).
X. Yin, A. S. Hoffman, and P. S. Stayton, Biomacromolecules 7, 1381 (2006).
H. Y. Tian, J. J. Yan, D. Wang, C. Gu, Y. Z. You, and X. S. Chen, Macromol. Rapid Commun. 32, 660 (2011).
L. I. Valuev, V. V. Chupov, O. N. Zefirova, T. L. Lebedeva, and N. A. Plate, Pure Appl. Chem. 67, 963 (1995).
E. Zeinali, V. Haddadi-Asl, and H. Roghani-Mamaqani, J. Biomed. Mater. Res 106, 231 (2018).
H. Nuhn and H. A. Klok, Biomacromolecules 9, 2755 (2008).
Y. H. Bae, T. Okano, and S. W. Kim, Pharm. Res. 8, 624 (1991).
R. Yoshida, K. Sakai, T. Okano, and Y. Sakurai, J. Biomater. Sci. 6, 585 (1994).
L. I. Valuev, O. N. Zefirova, I. V. Obydennova, and N. A. Plate, J. Bioact. Compat. Polym. 9, 55 (1994).
I. L. Valuev, I. V. Obydennova, L. V. Vanchugova, L. I. Valuev, N. A. Sivov, and T. A. Valueva, Polym. Sci., Ser. B 59, 80 (2017).
V. P. Torchilin, T. S. Levchenko, K. R. Whiteman, A. A. Yaroslavov, A. M. Tsatsakis, A. K. Rizos, E. V. Mi-chailova, and M. I. Shtilman, Biomaterials 22, 3035 (2001).
N. A. Plate and A. E. Vasil’ev, Physiologically Active Polymers (Khimiya, Moscow, 1986) [in Russian].
I. L. Valuev, I. V. Obydennova, I. M. Shanazarova, M. A. Rozenfel’d, and N. A. Plate, Dokl. Ross. Akad. Nauk 372, 189 (2000).
O. B. Ptitsyn, Usp. Sovr. Biol. 69, 26 (1970).
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The work was performed within the framework of the State Task for the Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences.
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Valuev, I.L., Vanchugova, L.V. & Valuev, L.I. Transport Functions of Polymers with a Lower Critical Solution Temperature. Polym. Sci. Ser. B 61, 430–432 (2019). https://doi.org/10.1134/S1560090419040146
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DOI: https://doi.org/10.1134/S1560090419040146