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Green and Efficient Synthesis of Novel N-Phenyl-2-(3H-thieno[2,3-d]imidazol-2-yl)benzamides

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Abstract

N-(Substituted phenyl)-2-(3H-thieno[2,3-d]imidazol-2-yl)benzamides were synthesized by one-pot three-component reaction of dimethyl phthalate, substituted anilines, and thiophene-2,3-diamine in a mixture of ethanol and water in the presence of H3PO4 as catalyst for 1.5–2.0 h at 70–75°C. The developed synthetic protocol is sustainable and economic and is characterized by easy workup procedure, the use of nontoxic reactants and solvents, short reaction time, and high yields.

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ACKNOWLEDGMENTS

The authors are thankful to the authorities of the Depart­ment of Chemistry, Acharya Nagarguna University, (Guntur, Andhra Pradesh, India) for providing laboratory facilities.

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  1. Department of Chemistry, Acharya Nagarguna University, 522510, Guntur, Andhra Pradesh, India

    K. Maram & R. Ramesh Raju

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  1. K. Maram
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  2. R. Ramesh Raju
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Correspondence to R. Ramesh Raju.

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Maram, K., Raju, R.R. Green and Efficient Synthesis of Novel N-Phenyl-2-(3H-thieno[2,3-d]imidazol-2-yl)benzamides. Russ J Org Chem 58, 1030–1034 (2022). https://doi.org/10.1134/S1070428022070132

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  • DOI: https://doi.org/10.1134/S1070428022070132

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