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On Reactions of 5-Imino-N,4-diaryl-4,5-dihydro-1,2,4-thiadiazol-3-amines with Phenylethynyl Sulfones

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Abstract

N-Arylthioureas were reacted with hydrogen peroxide to synthesize 5-imino-N,4-diaryl-4,5-dihydro-1,2,4-thiadiazol-3-amines (Ar = Ph, p-Tol, 4-BrC6H4). The products undewent 1,3-dipolar cycloaddition to (R-ethynyl)sulfonyl benzoles (R = Me, Ph, p-Tol, CF3) under mild conditions to form, in each case, a mixture of the corresponding 5-sulfonyl-substituted N,4-diarylthiazole-2-amines and N-arylcyanamides.

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Authors and Affiliations

  1. National Research Mordovia State University, 430005, Saransk, Russia

    S. G. Kostryukov, Yu. Yu. Masterova & E. Yu. Pugacheva

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  1. S. G. Kostryukov
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  2. Yu. Yu. Masterova
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  3. E. Yu. Pugacheva
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Correspondence to S. G. Kostryukov.

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Kostryukov, S.G., Masterova, Y.Y. & Pugacheva, E.Y. On Reactions of 5-Imino-N,4-diaryl-4,5-dihydro-1,2,4-thiadiazol-3-amines with Phenylethynyl Sulfones. Russ J Org Chem 58, 219–225 (2022). https://doi.org/10.1134/S1070428022020099

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