Abstract
A green and eco-friendly synthesis of novel 2-(1H-indol-3-yl)-3-phenyl-2,3-dihydroquinazolin-4(1H)-one derivatives have been developed using L-proline as a simple catalyst. Two efficient methods have been described for the synthesis of dihydroquinazolin-4(1H)-one derivatives. In the first method, 1H-1,3-benzoxazine-2,4-dione reacted with substituted anilines and 1H-indole-3-carbaldehydes in water in the presence of L-proline as a catalyst, whereas in the second method, a similar reaction using 1H-indol-3-ylmethanol instead of indole-3-carbaldehyde was catalyzed by L-proline/K2CO3 at room temperature for 30 min to afford the same products. These two protocols involve eco-friendly and inexpensive catalysts and produce the target products in excellent yields with a sufficient purity, so that there was no need of column chromatography for their isolation or purification.
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The authors are grateful to the management of Dr. Reddy’s Laboratories Ltd. for supporting this work and highly appreciate the co-operation from all the supporting function colleagues.
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Hari Krishna Reddy, V., Prashanth Reddy, G., Krishna Mohan, T. et al. L-Proline/K2CO3-Catalyzed Eco-friendly Synthesis of Novel 2-(1H-Indol-3-yl)-3-phenyl-2,3-dihydroquinazolin-4(1H)-one Derivatives. Russ J Org Chem 57, 1678–1684 (2021). https://doi.org/10.1134/S1070428021100171
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DOI: https://doi.org/10.1134/S1070428021100171