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First Stereoselective Total Synthesis of Modiolin

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Abstract

The first stereoselective total synthesis of the linear pentaketide Modiolin has been performed via Jacobsen’ hydrolytic kinetic resolution and 2C-Wittig homologation as key steps.

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ACKNOWLEDGMENTS

The authors are pleased to express their gratitude to the CSIR, New Delhi for financial assistance [project no. 02(0197)/14/EMR-II].

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Authors and Affiliations

  1. Department of Organic Chemistry, Dr. B. R. Ambedkar University, 532410, Srikakulam, India

    G. Padma Rao

  2. National Centre for Polar and Ocean Research, Ministry of Earth Sciences, 403804, Goa, India

    B. Sathish Mohan

  3. Department of Organic Chemistry and FDW, Andhra University, 530003, Visakhapatnam, India

    V. Siddaiah

Authors
  1. G. Padma Rao
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  2. B. Sathish Mohan
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  3. V. Siddaiah
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Correspondence to V. Siddaiah.

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Rao, G.P., Mohan, B.S. & Siddaiah, V. First Stereoselective Total Synthesis of Modiolin. Russ J Org Chem 56, 2028–2031 (2020). https://doi.org/10.1134/S1070428020110184

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  • DOI: https://doi.org/10.1134/S1070428020110184

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