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Synthesis of Substituted 4-(Thiophen-2-yl)nicotinonitriles

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Abstract

A series of 4-(thiophen-2-yl)-substituted nicotinonitriles were prepared by a three step procedure including condensation and cyclization of 2-acetylthiophene. A more efficient synthesis of the target products is proposed and the transformation of some of the synthesized nicotinonitrles into 1H-pyrazolo[3,4-b]pyridines is described.

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Funding

The work was financially supported by the Committee for Education, Science and Sports of the Republic of Armenia (grant no. 18T-2E151).

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Authors and Affiliations

  1. Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia, 0014, Yerevan, Armenia

    R. M. Hakobyan, H. S. Attaryan & S. S. Hayotsyan

  2. Yerevan State University, 0025, Yerevan, Armenia

    G. S. Melikyan

Authors
  1. R. M. Hakobyan
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  2. H. S. Attaryan
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  3. G. S. Melikyan
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  4. S. S. Hayotsyan
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Corresponding author

Correspondence to S. S. Hayotsyan.

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The authors declare no conflict of interest.

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Hakobyan, R.M., Attaryan, H.S., Melikyan, G.S. et al. Synthesis of Substituted 4-(Thiophen-2-yl)nicotinonitriles. Russ J Org Chem 56, 356–360 (2020). https://doi.org/10.1134/S1070428020020323

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  • DOI: https://doi.org/10.1134/S1070428020020323

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