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Synthesis and Evaluation of Pyrazole Derivatives as Potent Antinemic Agents

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Abstract

Pyrazole derivatives were synthesized by bromination of pyrazole, followed by N-alkylation of 4-bromopyrazole. The synthesized derivatives were characterized by microanalytical data and IR and 1H and 13C NMR spectra and were evaluated for their nematicidal activity against the root knot nematode Meloidogyne incognita. The compounds were screened for their egg hatch inhibition and mortality potential, and they showed significant nematicidal activity as compared to the control. 1H-Pyrazol-5(4H)-one was found to be most effective in egg hatch inhibition, and 4-bromopyrazole was found to be most effective in juvenile mortality.

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Acknowledgments

The authors gratefully acknowledge Sophisticated Analytical Instrumentation Facility, Panjab University, Chandigarh, for the analysis of compounds reported in this article.

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Authors and Affiliations

  1. Department of Chemistry, Punjab Agricultural University, Ludhiana, 141027, Punjab, India

    G. Kaur, D. Utreja & N. Jain

  2. Department of Plant Pathology, Punjab Agricultural University, Ludhiana, 141027, Punjab, India

    N. K. Dhillon

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  1. G. Kaur
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  2. D. Utreja
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  4. N. K. Dhillon
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Correspondence to D. Utreja.

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Kaur, G., Utreja, D., Jain, N. et al. Synthesis and Evaluation of Pyrazole Derivatives as Potent Antinemic Agents. Russ J Org Chem 56, 113–118 (2020). https://doi.org/10.1134/S1070428020010182

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  • DOI: https://doi.org/10.1134/S1070428020010182

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