Skip to main content
SpringerLink
Log in

Three-component synthesis of methyl 6-alkyl-3-cyano-2-halopyridine-4-carboxylates

  • Published:
Russian Journal of Organic Chemistry Aims and scope Submit manuscript

Abstract

A procedure has been developed for the synthesis of methyl 6-alkyl-3-cyano-2-halopyridine-4-carboxylate by three-component reaction of 4-oxoalkane-1,1,2,2-tetracarbonitriles with hydrogen halides in methanol.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Tsarichenko, G.V., Bobrov, V.I., and Starkov, M.V., Pharm. Chem. J., 1977, vol. 11, p. 481.

    Article  Google Scholar 

  2. Suarez, J., Ranguelova, K., and Jarzecki, A.A., J. Biol. Chem., 2009, vol. 284, p. 7017.

    Article  CAS  Google Scholar 

  3. Ershov, O.V., Fedoseev, S.V., Belikov, M.Yu., and Ievlev, M.Yu., RSC Adv., 2015, vol. 5, p. 34 191.

    Article  CAS  Google Scholar 

  4. Ershov, O.V., Lipin, K.V., Maksimova, V.N., Eremkin, A.V., Kayukov, Ya.S., and Nasakin, O.E., Russ. J. Org. Chem., 2009, vol. 45, p. 475.

    Article  CAS  Google Scholar 

  5. Ershov, O.V., Maksimova, V.N., Lipin, K.V., Belikov, M.Y., Ievlev, M.Y., Tafeenko, V.A., and Nasakin, O.E., Tetrahedron, 2015, vol. 71, no. 39, 7445.

    Article  CAS  Google Scholar 

  6. Eremkin, A.V., Molkov, S.N., Ershov, O.V., Kayukov, Y.S., Nasakin, O.E., Tafeenko, V.A., and Nurieva, E.V., Mendeleev Commun., 2006, vol. 16, no. 2, p. 115.

    Article  Google Scholar 

  7. Yashkanova, O.V., Lukin, P.M, Nasakin, O.E., Urman, Ya.G., Khrustalev, V.N., Nesterov, V.N., Antipin, M.Yu., and Vershinin, E.V., Russ. J. Org. Chem., 1997, vol. 33, p. 484.

    CAS  Google Scholar 

  8. Bardasov, I.N., Alekseeva, A.U., Mihailov, D.L., Ershov, O.V., Nasakin, O.E., and Tafeenko, V.A., Tetrahedron Lett., 2014, vol. 55, p. 2730.

    Article  CAS  Google Scholar 

  9. Fedoseev, S.V., Ershov, O.V., Belikov, M.Yu., Lipin, K.V., Bardasov, I.N., Nasakin, O.E., and Tafeenko, V.A., Tetrahedron Lett., 2013, vol. 54, p. 2143.

    Article  CAS  Google Scholar 

  10. Yoshida, K. and Otomasu, H., Yakugaku Zasshi, 1976, vol. 96, no. 1, p. 33.

    CAS  Google Scholar 

  11. Havas, F., Leygue, N., Danel, M., Mestre, B., Galaup, C., and Picard, C., Tetrahedron, 2009, vol. 55, no. 36, p. 7673.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. I.N. Ul’yanov Chuvash State University, Moskovskii pr. 15, Cheboksary, 428015, Russia

    O. V. Ershov, K. V. Lipin & O. E. Nasakin

Authors
  1. O. V. Ershov
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. K. V. Lipin
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. O. E. Nasakin
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to K. V. Lipin.

Additional information

Original Russian Text © O.V. Ershov, K.V. Lipin, O.E. Nasakin, 2016, published in Zhurnal Organicheskoi Khimii, 2016, Vol. 52, No. 7, pp. 977–980.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Ershov, O.V., Lipin, K.V. & Nasakin, O.E. Three-component synthesis of methyl 6-alkyl-3-cyano-2-halopyridine-4-carboxylates. Russ J Org Chem 52, 970–973 (2016). https://doi.org/10.1134/S1070428016070071

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S1070428016070071

Search

Navigation