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Synthesis of 5-arylisoxazole- and 4,5-dichloroisothiazole-3-carboxylates derived from natural alcohols, thymol, and its synthetic analogs

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Abstract

Esters derived from 5-phenyl-, 5-(4-methylphenyl)-, and 5-(2,5-dimethylphenyl)-1,2-oxazole-3-carboxylic and 4,5-dichloro-1,2-thiazole-3-carboxylic acids and some natural alcohols (L-menthol, grosshemin), thymol, and synthetic analogs of the latter (4-tert-butylphenol, 4-tert-octylphenol, 2-tert-butyl-4-methylphenol) were synthesized by reactions of the corresponding alcohols with acid chlorides.

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Authors and Affiliations

  1. Institute of Physical Organic Chemistry, National Academy of Sciences of Belarus, ul. Surganova 13, Minsk, 220072, Belarus

    S. K. Petkevich, E. A. Dikusar, N. A. Zhukovskaya, A. V. Kletskov, N. G. Kozlov & V. I. Potkin

  2. Phytochemistry International Research and Production Holding, ul. M. Gazalieva 4, Karaganda, Kazakhstan

    A. S. Kishkentaeva, O. G. Ryazantsev, G. A. Atazhanova & S. M. Adekenov

  3. Institute of Physiology, National Academy of Sciences of Belarus, ul. Akademicheskaya 28, Minsk, 220072, Belarus

    S. G. Pashkevich, A. A. Denisov & V. A. Kul’chitskii

Authors
  1. S. K. Petkevich
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  2. A. S. Kishkentaeva
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  3. O. G. Ryazantsev
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  4. E. A. Dikusar
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  5. N. A. Zhukovskaya
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  6. A. V. Kletskov
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  7. N. G. Kozlov
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  8. G. A. Atazhanova
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  9. S. M. Adekenov
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  10. V. I. Potkin
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  11. S. G. Pashkevich
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  12. A. A. Denisov
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  13. V. A. Kul’chitskii
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Corresponding author

Correspondence to E. A. Dikusar.

Additional information

Original Russian Text © S.K. Petkevich, A.S. Kishkentaeva, O.G. Ryazantsev, E.A. Dikusar, N.A. Zhukovskaya, A.V. Kletskov, N.G. Kozlov, G.A. Atazhanova, S.M. Adekenov, V.I. Potkin, S.G. Pashkevich, A.A. Denisov, V.A. Kul’chitskii, 2014, published in Zhurnal Organicheskoi Khimii, 2014, Vol. 50, No. 9, pp. 1366–1371.

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Petkevich, S.K., Kishkentaeva, A.S., Ryazantsev, O.G. et al. Synthesis of 5-arylisoxazole- and 4,5-dichloroisothiazole-3-carboxylates derived from natural alcohols, thymol, and its synthetic analogs. Russ J Org Chem 50, 1351–1356 (2014). https://doi.org/10.1134/S107042801409019X

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  • DOI: https://doi.org/10.1134/S107042801409019X

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