Abstract
Novel less than 100 nm sized magnetic Co0.5Mn0.5Fe2O4-chitosan nanoparticles advantageous in respect of excellent biodegradation and high level of controllability are successfully prepared. TEM and SEM images showed the cubic-shape magnetic Co0.5Mn0.5Fe2O4 particles were encapsulated by spherical chitosan nanoparticles. The release behavior of bovine serum albumin entrapped in the particles was of distinctly difference with the changes of pH value of loading medium. The release of bovine serum albumin in those two kinds of particles in the medium of pH=1.0 was much quicker in pH = 7.4 and 9.18. The amount of Bovine serum albumin (BSA) released from the particles at different time intervals was estimated using UV spectrophotomertic method at 279 nm. The dissolution profile and in vitro release kinetics showed that Co0.5Mn0.5Fe2O4-chitosan nanoparticles were promising for controlled delivery of the drug.
Similar content being viewed by others
References
Dee, J.D., Rhode, O., and Wachter, R., Cosmetics and Toiletries, 2001, vol. 116, p. 39.
Singla, A.K. and Chawla, M.J., Pharm. Pharmacol, 2001, vol. 53, p. 1047.
No, H.K. and Meyers, S.P.J., Agric. Food Chem., 1989, vol. 37, p. 580.
Kurita, K., Polym. Degrad. Stabil., 1998, vol. 59, p. 117.
Baily, S.E., Olin, T.J., Bricka, R.M., Adrian, D.D., Water Res., 1999, vol. 33, p. 2469.
Yanga Jen-Kuo, Shibb Ing-Lung, Tzengc, Yew-Min Wang, and San Lang, Enzyme Microb. Technol., 2000, vol. 26, p. 406.
Pillai, O. and Panchagnula, R., Curr. Opin. Chem. Biol., 2001, vol. 5, p. 447.
Khor, E. and Lim., L.Y., Biomater., 2003, vol. 24, p. 2339.
Yuan, S. and Wei, T.J., Bioact. Compat. Polym., 2004, vol. 19, p. 467.
Crini, G., Bioresour. Technol., 2006, vol. 97, p. 1061.
Kerec, M, Bogataj, M, Veranic, P., et al., Eur. J. Pharm. Sci., 2005, vol. 25, no. 1, p. 113.
Chen, L.Y., Tian, Z.G., and Du, Y.M., Biomaterials, 2004, vol. 25, no. 17, p. 3725.
Lin, Y.H., Liang, H.F., and Chung, C.K., et al., Biomaterials, 2005, vol. 26, no. 14, p. 2105.
Roger, J., Pons, J.N., Massart, R., Halbreich, A., and Bacri, J., Eur. Phys. J.: Appl. Phys., 1999, vol. 5, p. 321.
Author information
Authors and Affiliations
Additional information
The text was submitted by the authors in English.
Rights and permissions
About this article
Cite this article
Zheng, X., Lian, Q. & Wu, H. Aggregation of magnetic chitosan based nanoparticles and their application in controlled drug release. Russ J Appl Chem 88, 524–528 (2015). https://doi.org/10.1134/S1070427215030246
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S1070427215030246