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Synthesis of Pyrrolidine-2,3-dione Derivatives by Reacting Methyl 4-(4-Fluorophenyl)-2,4-dioxobutanoate with Tryptamine and Aromatic Aldehydes

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Abstract

Short-term heating of a mixture of tryptamine, aromatic aldehyde, and methyl 4-(4-fluorophenyl)-2,4-dioxobutanoate, followed by keeping for a day at room temperature, leads to the formation of 5-aryl-1-[2-(1H-indol-3-yl)-ethyl]-4-[(4-fluorophenyl)(hydroxy)methylene]pyrrolidine-2,3-diones. Structure of the obtained compounds was confirmed by IR and NMR spectroscopy methods.

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Funding

This work was financially supported by the Perm Scientific and Educational Center “Rational Subsoil Use” (2022).

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Authors and Affiliations

  1. E.A. Wagner Perm State Medical University, 614000, Perm, Russia

    M. I. Kazantseva

  2. Perm State Pharmaceutical Academy, 614990, Perm, Russia

    T. M. Zamaraeva & V. L. Gein

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  1. M. I. Kazantseva
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  2. T. M. Zamaraeva
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  3. V. L. Gein
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Correspondence to V. L. Gein.

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Kazantseva, M.I., Zamaraeva, T.M. & Gein, V.L. Synthesis of Pyrrolidine-2,3-dione Derivatives by Reacting Methyl 4-(4-Fluorophenyl)-2,4-dioxobutanoate with Tryptamine and Aromatic Aldehydes. Russ J Gen Chem 92, 949–954 (2022). https://doi.org/10.1134/S1070363222060056

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