Abstract
In the current study, some new quinoxaline linked 1,3,4-oxadiazole sulfonamide hybrids have been designed, synthesized and characterized by IR, 1H and 13C NMR, and mass spectra. The products have been evaluated for their in vitro anti-proliferative activity against four human cancer cell lines, namely HeLa (cervical), A549 (lung), MCF-7 (breast), HEK-293 (embryonic kidney). Three compounds have demonstrated high anticancer activity when compared with Etoposide used as a reference drug.
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ACKNOWLEDGMENTS
The authors are thankful to the Department of Chemistry, Chaitanya Deemed to be University for providing Laboratory facilities and Department of Biotechnology, Chaitanya Deemed to be University for their support in anticancer activity.
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Ravula, S., Nukala, S.K., Thirukovela, N.S. et al. Design, Synthesis, and Anti-Proliferative Activity of Some New Quinoxaline-1,3,4-oxadiazole Sulfonamide Hybrids. Russ J Gen Chem 92, 702–708 (2022). https://doi.org/10.1134/S1070363222040119
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DOI: https://doi.org/10.1134/S1070363222040119