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Synthesis and Antifungal Activity of New N-Aryl-2-(2-hydroxyphenylamino)ethylenediamine Derivatives

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Abstract

In this study, a series of new N-aryl-2-(2-hydroxyphenylamino)ethylenediamine derivatives has been designed, synthesized and evaluated for antifungal activity against six selected species of phytopathogenic fungi. Among the products, the most potent compound have demonstrated 97.7% inhibitory activity against S. sclerotiorum at the concentration of 50 μg/mL, which is higher than that of the positive control chlorothalonil.

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Funding

This work was supported by National Natural Science Foundation of China (grant no. 82003602, 21877034), Natural Science Foundation of Hunan Province of China (grant no. 2019JJ50145) and Scientific Research Fund of Hunan Provincial Education Department (grant no. 18C0325).

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Authors and Affiliations

  1. Key Laboratory of Theoretical Organic Chemistry and Functional Molecule, Ministry of Education, School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, 411201, Hunan, Xiangtan, China

    Han Gao, Yichao Wan, Yuhuan Tan, Xi Luo & Lin Li

  2. Hunan Provincial Key Laboratory of Controllable Preparation and Functional Application of Fine Polymers, Hunan Provincial Key Lab of Advanced Materials for New Energy Storage and Conversion, Hunan University of Science and Technology, 411201, Hunan, Xiangtan, China

    Yichao Wan

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  1. Han Gao
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  2. Yichao Wan
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  3. Yuhuan Tan
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  4. Xi Luo
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Correspondence to Yichao Wan.

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Gao, H., Wan, Y., Tan, Y. et al. Synthesis and Antifungal Activity of New N-Aryl-2-(2-hydroxyphenylamino)ethylenediamine Derivatives. Russ J Gen Chem 91, 122–127 (2021). https://doi.org/10.1134/S107036322101014X

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