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Design, Synthesis, and Evaluation of Isoxazole-Thiadiazole Linked Carbazole Hybrids as Anticancer Agents

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Abstract

A series of isoxazole-thiadiazole linked carbazole derivatives 12a–12j are synthesized and their chemical structures confirmed by 1H and 13C NMR and mass spectra. The products are tested for their anticancer activity against human cancer cell lines: MCF-7 (breast), A549 (lung), DU-145 (prostate), and MDA MB-231 (breast) by using MTT assay and etoposide as a reference drug. The accumulated data indicate that most of the compounds demonstrate anticancer activity higher than etoposide.

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Authors and Affiliations

  1. Department of Chemistry, Krishna University, Machilipatnam, Andhra Pradesh, 521001, India

    B. V. Durga Rao & M. V. Basaveswara Rao

  2. Department of Chemistry, University College of Engineering (Autonomous), Jawaharlal Nehru Technological University, Kakinada, Andhra Pradesh, 533003, India

    R. Sreenivasulu

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  1. B. V. Durga Rao
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  2. R. Sreenivasulu
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  3. M. V. Basaveswara Rao
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Correspondence to M. V. Basaveswara Rao.

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Durga Rao, B.V., Sreenivasulu, R. & Basaveswara Rao, M.V. Design, Synthesis, and Evaluation of Isoxazole-Thiadiazole Linked Carbazole Hybrids as Anticancer Agents. Russ J Gen Chem 89, 2115–2120 (2019). https://doi.org/10.1134/S1070363219100207

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  • DOI: https://doi.org/10.1134/S1070363219100207

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