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Microwave-assisted synthesis of pyrazole-based 1,2,3-triazole derivatives and evaluation of their antimicrobial activity

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Abstract

A series of new pyrazole-based 1,2,3-triazole derivatives were synthesized through the microwave-assisted Huisgen click reaction from 1-phenyl-3-[3-(prop-2-yn-1-yloxy)phenyl]-1H-pyrazole-4-carbaldehyde and organic azides with the use of redox system CuSO4·5H2O–sodium ascorbate. The method provided short reaction times and isolation of 1,4-disubstituted 1,2,3-triazoles in high yield. All the prepared compounds were evaluated for antimicrobial activity and the most of them displayed promising results.

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Authors and Affiliations

  1. Department of Chemistry, University College of Technology, Osmania University, Hyderabad, 500007, India

    N. J. P. Subhashini, K. Sravanthi & Ch. Sravanthi

  2. Department of Pharmaceutical Chemistry, Vaageswari College of Pharmacy, Thimmapur, Karimnagar, Telangana, 505481, India

    M. S. Reddy

Authors
  1. N. J. P. Subhashini
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  2. K. Sravanthi
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  3. Ch. Sravanthi
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  4. M. S. Reddy
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Correspondence to N. J. P. Subhashini.

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Subhashini, N.J.P., Sravanthi, K., Sravanthi, C. et al. Microwave-assisted synthesis of pyrazole-based 1,2,3-triazole derivatives and evaluation of their antimicrobial activity. Russ J Gen Chem 86, 2777–2784 (2016). https://doi.org/10.1134/S1070363216120392

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  • DOI: https://doi.org/10.1134/S1070363216120392

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