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NMR study of 1,7-diamino-4-oxyheptane-1,1,7,7-tetraphosphonic acid interaction with samarium(III) cation

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Abstract

1,7-Diamino-4-oxypentane-1,1,7,7-tetraphosphonic acid has been synthesized while searching for potential components for 153Sm radiopharmaceuticals. Its interaction with samarium(III) cation has been studied by 13C and 31P NMR spectroscopy in comparison with 1,5-diamino-3-oxypentane-N,N'-tetra-(methylenephosphonic acid) which is the ligand component of the osteotropic drug Samarium 153Sm oxabifore. NMR spectroscopy provides a simple, convenient, and informative method for studying interactions between the ligand and prospective radionuclide cation.

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Authors and Affiliations

  1. Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences, Leninskii pr. 31/4, Moscow, 119071, Russia

    G. S. Tsebrikova, V. E. Baulin, I. P. Kalashnikova & A. Yu. Tsivadze

  2. Institute of Physiologically Active Compounds, Russian Academy of Sciences, Severnyi proezd 1, Chernogolovka, Moscow oblast, Russia

    V. E. Baulin, I. P. Kalashnikova, V. V. Ragulin & V. O. Zavel’skii

  3. Burnazyan Federal Medical Biophysical Center, Federal Medical Biological Agency of Russia, ul. Zhivopisnaya 46, Moscow, 123098, Russia

    G. E. Kodina

Authors
  1. G. S. Tsebrikova
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  2. V. E. Baulin
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  3. I. P. Kalashnikova
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  4. V. V. Ragulin
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  5. V. O. Zavel’skii
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  6. G. E. Kodina
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  7. A. Yu. Tsivadze
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Correspondence to G. S. Tsebrikova.

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Original Russian Text © G.S. Tsebrikova, V.E. Baulin, I.P. Kalashnikova, V.V. Ragulin, V.O. Zavel’skii, G.E. Kodina, A.Yu. Tsivadze, 2016, published in Zhurnal Obshchei Khimii, 2016, Vol. 86, No. 3, pp. 499–504.

To the 100th Anniversary of A.N. Pudovik

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Tsebrikova, G.S., Baulin, V.E., Kalashnikova, I.P. et al. NMR study of 1,7-diamino-4-oxyheptane-1,1,7,7-tetraphosphonic acid interaction with samarium(III) cation. Russ J Gen Chem 86, 639–644 (2016). https://doi.org/10.1134/S107036321603021X

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  • DOI: https://doi.org/10.1134/S107036321603021X

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