Abstract
A new N-sulfonamide ligand, N-(5-(4-methylphenyl)-[1,3,4]-thiadiazole-2-yl)toluenesulfonamide (HL) and its Cu(II) complex [Cu(L)2(Py)2(H2O)] (I), have been synthesized. The X-ray crystal structure of the ligand and of complex I have been determined (CIF files CCDC nos. 975153 (HL), 851790 (I)). In I, the Cu2+ ion is five-coordinated, forming a CuN4O chromophore. The ligand acts as monodentate, coordinating the metal ion through a single Nthiadiazole atom. The molecules from the reaction medium (pyridine and water) are also involved in the coordination of the Cu2+ ion. Complex I has a slightly distorted square pyramidal geometry. The complex was characterized by FT-IR, electronic, EPR spectroscopic and magnetic methods. The nuclease activity studies of the synthesized complex confirm his capacity to cleavage the DNA molecule. The ligand has two important roles in the nuclease activity of I: it influence the reactivity of the Cu2+ ion and interact with DNA molecule. The complex interacts with the DNA molecule. Immediately, the Cu2+ ion is reduced to Cu(I), and in the presence of molecular oxygen the formed Cu(I) complex produces reactive oxygen species in close proximity to the double helix.
Similar content being viewed by others
References
Liu, C., Zhou, J., Li, Q., et al., J. Inorg. Chem., 1999, vol. 75, p. 233.
Theodorou, A., Demertzis, M.A., and Kovala-Demertzis, D., Biometals, 1999, vol. 12, p. 167.
Sigman, D.S., Kuwabara, M.D., Chen, C.H., et al., Methods Enzymol., 1991, vol. 208, p. 414.
Gonzalez-Alvarez, M., Alzuet, G., Borras, J., et al., Inorg. Chem., 2003, vol. 42, p. 2992.
Gonzalez-Alvarez, M., Alzuet, G., Borras, J., et al., J. Biol. Inorg. Chem., 2003, vol. 8, p. 644.
Marcias, B., Garcia, I., Villa, M.V., et al., Inorg. Chim. Acta, 2003, vol. 353, p. 139.
Garcia-Gimenez, J.L., Alzuet, G., Gonzalez-Alvarez, M., et al., J. Inorg. Chem., 2007, vol. 46, p. 7178.
Hangan, A., Borras, J., Liu-Gonzalez, M., et al., Z. Anorg. Allg. Chem., 2007, vol. 633, p. 1837.
Gonzalez-Alvarez, M., Alzuet, G., Borras, J., et al., J. Biol. Inorg. Chem., 2008, vol. 13, p. 1249.
Thomas, A.M., Nethaji, M., Chakravarty, A.R., J. Inorg. Biochem., 2004, vol. 98, p. 1087.
Owa, T., Yoshino, H., Okauchi, T., et al., J. Med. Chem., 1999, vol. 42, p. 3789.
Cedujo, R., Alzuet, G., Gonzalez-Alvarez, M., et al., J. Inorg. Biochem., 2006, vol. 100, p. 70.
Gonzalez-Alvarez, M., Alzuet, G., Castillo-Agudo, L., et al., Eur. J. Inorg. Chem., 2006, vol. 19, p. 3823.
Marcias, B., Villa, M.J., Gomez, B., et al., J. Inorg. Biochem., 2006, vol. 101, p. 444.
Garcia-Gimenez, J.L., Alzuet, G., Gonzalez-Alvarez, M., et al., J. Inorg. Biochem., 2009, vol. 103, p. 243.
CrysAlis PRO CCD and CrysAlis PRO RED, Oxford Diffraction Ltd., Abingdon, 2006.
SCALE3 ABSPACK, Empirical Absorption Correction, CrysAlis-Software Package, Oxford Diffraction Ltd., 2006.
Sheldrick G.M., SHELXS-97, Program for Crystal Structure Solution, Göttingen (Germany): Univ. of Göttingen, 1997.
Sheldrick G.M., SHELXL-97, Program for the Refinement of Crystal Structures, Göttingen (Germany): Univ. of Göttingen, 1997.
Dolomanov, O.V., Bourhis, L.J., Gildea, et al., J. Appl. Cryst., 2009, vol. 42, p. 339.
Wilson A.J.C., International Tables for Crystallography, vol. C, Dordrecht (The Netherlands): Kluwer Academic Publishers, 1995.
Spek A.L., PLATON, A Multipurpose Crystallographic Tool, Utrecht (The Netherlands): Utrecht Univ., 2000.
Keller E., SCHAKAL-97, A Computer Program for the Graphic Representation of Molecular Crystallographic Models, Freiburg (Germany): Univ. of Freiburg, 1997.
Alzuet, G., Ferrer, S., and Borras, J., Acta Crystallogr., C, 1991, vol. 47, p. 2377.
Pedregosa, J.C., Alzuet, G., and Borras, J., Acta Crystallogr., C, 1993, vol. 49, p. 630.
Allen, A.M., Kennard, O., Watson, D.G., et. al. Trans. Perkin 2, 1987, p. S1.
Borras, E., Alzuet, G., Borras, J., et al., Polyhedron, 2000, vol. 19, p. 1859.
Ferrer, S., Haasnoot, J.G., Graaf, R.A.G., et al., Inorg. Chim. Acta, 1992, vol. 192, p. 129.
Graf, M., Greaves, B., and Stoeckli-Evans, H., Inorg. Chim. Acta, 1993, vol. 204, p. 239.
Adison, A.W., Rao, T.N., Reedijk, J., et al., Dalton Trans., 1984, p. 1349.
Koon, N., Wong, S., and Colson, D., J. Mol. Spectrosc., 1984, vol. 104, p. 129.
Gonzalez-Alvarez, M., Alzuet, G., Borras, J., et al., J. Inorg. Biochem., 2004, vol. 98, p. 189.
Marcias, B., Garcia, I., Villa, M.V., et al., J. Inorg. Biochem., 2003, vol. 96, p. 367.
Cami, G.E., Ramirez de Arellano, M.C., Fustero, S., et al., An. Asoc. Quim. Argent., 2006, p. 941.
Otter, C.A., Couchman, S.M., Jeffery, J.C., et al., Inorg. Chim. Acta, 1998, vol. 278, p. 178.
Alzuet, G., Ferrer, S., Borras, J., et al., Inorg. Chim. Acta, 1993, vol. 203, p. 257.
Hathaway, B.J., In: Comprehensive Coordination Chemistry, ch. 9, Wilkinson, G., Gillard, R.D., McCleverty, J.A., Eds., New York: Pergamon, 1987.
WINEPR-Simfonia 1.25, Karlsruhe: Bruker Analytik GmbH, 1994–1996.
Bertini, I. and Drago, R., ESR and NMR of Paramagnetic Species in Biological and Related Systems, Dordrecht: D. Reidel, 1979.
Gonzalez-Alvarez, M., Alzuet, G., Borras, J., et al., J. Inorg. Biochem., 2002, vol. 89, p. 29.
Li, L., Karlin, K.D., and Rokita, S.E., J. Am. Chem. Soc., 2005, vol. 127, p. 520.
Humphreys, K.J., Karlin, K.D., and Rokita, S.E., J. Am. Chem. Soc., 2002, vol. 124, p. 8055.
Pamatong, F.V., Detmer, C.A. III, and Bocarsly, J.R., J. Am. Chem. Soc., 1996, vol. 118, p. 5339.
Detmer, C.A. III, Pamatong, F.V., and Bocarsly, J.R., Inorg. Chem., 1996, vol. 35, p. 6292.
Author information
Authors and Affiliations
Corresponding author
Additional information
The article is published in the original.
Rights and permissions
About this article
Cite this article
Hangan, A.C., Turza, A., Stan, R.L. et al. Synthesis, crystal structure, properties, and nuclease activity of a new Cu(II) complex [Cu(L)2(Py)2(H2O)] (HL = N-(5-(4-methylphenyl)-[1,3,4]-thiadiazole-2-yl)toluenesulfonamide). Russ J Coord Chem 41, 395–404 (2015). https://doi.org/10.1134/S1070328415050024
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S1070328415050024