Skip to main content
SpringerLink
Log in

Effect of Nanodispersions with Lipoic Acid and Its Esters on the Functional Activity of Neutrophils and Platelets

  • Published:
Russian Journal of Bioorganic Chemistry Aims and scope Submit manuscript

Abstract

The effect of nanodispersions with lipoic acid and its esters on the activity of lactate dehydrogenase in neutrophils and platelets has been studied. It has been shown that nanoparticles with lipoic acid and its esters decrease the activity of lactate dehydrogenase in neutrophils and platelets 1.5–2 times, which indicates that nanodispersions containing lipoic acid and its conjugates decrease the concentration of reactive oxygen species in activated neutrophils and platelets 2–3 times. Studies on the inhibition of free radical processes in neutrophils and platelets showed that the nanoforms with lipoic acid and its esters possess an antioxidant activity.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1.
Fig. 2.
Fig. 3.
Fig. 4.
Fig. 5.

Similar content being viewed by others

REFERENCES

  1. Kulesh, A.A., Demin, D.A., and Vinogradov, O.I., Cons. Med., 2021, vol. 23, pp. 792–799. https://doi.org/10.26442/20751753.2021.11.201153

    Article  Google Scholar 

  2. Orellana-Urzúa, S., Rojas, I., Líbano, L., and Rodrigo, R., Curr. Pharm. Des., 2020, vol. 26, P. 4246–4260. https://doi.org/10.2174/1381612826666200708133912

  3. Quinlan, C.L., Perevoshchikova, I.V., Hey-Mogensen, M., Orr, A.L., and Brand, M.D., Redox Biol., 2013, vol. 1, pp. 304–312. https://doi.org/10.1016/j.redox.2013.04.005

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Maczurek, A., Hager, K., Kenklies, M., Sharman, M., Martins, R., Engel, J., Carlson, D.A., and Münch, G., Adv. Drug Deliv. Rev., 2008, vol. 60, pp. 1463–1470. https://doi.org/10.1016/j.addr.2008.04.015

    Article  CAS  PubMed  Google Scholar 

  5. Alban, F.T.E., Rowan, D.G., Golen, F., and Heger, M., The Liver. Oxidative Stress and Dietary Antioxidants, Patel, V.B., Rajendram, R., and Preedy, V.R., Eds., London: Academic, 2018, pp. 109–119. https://doi.org/10.1016/B978-0-12-803951-9.00010-0

  6. Shay, K.P., Moreau, R.F., Smith, E.J., Smith, A.R., and Hagen, T.M., Biochim. Biophys. Acta, 2009, vol. 1790, pp. 1149–1160. https://doi.org/10.1016/j.bbagen.2009.07.026

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Najafi, N., Mehri, S., Ghasemzadeh Rahbardar, M., and Hosseinzadeh, H., Phytother. Res., 2022, vol. 36, pp. 2300–2323. https://doi.org/10.1002/ptr.7406

    Article  CAS  PubMed  Google Scholar 

  8. Teoh, W.P., Resko, Z.J., Flury, S., and Alonzo, F., J. Bacteriol., 2019, vol. 201, pp. 1–14. https://doi.org/10.1128/JB.00446-19

    Article  Google Scholar 

  9. Du, J., Li, X., Lin, C., and He, X., Inflammation, 2016, vol. 38, pp. 1458–1463. https://doi.org/10.1007/s10753-015-0120-6

    Article  CAS  Google Scholar 

  10. Palaniappan, A.R. and Dai, A., Neurochem. Res., 2010, vol. 32, pp. 1552–1558. https://doi.org/10.1007/s11064-007-9355-4

    Article  CAS  Google Scholar 

  11. Salehi, B., Berkay Yılmaz, Y., and Antika, G., Biomolecules, 2019, vol. 9, pp. 356–359. https://doi.org/10.3390/biom9080356

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Brufani, M. and Figliola, R., Acta Biomed., 2014, vol. 85, pp. 108–115.

    PubMed  Google Scholar 

  13. Gruzman, A., Hidmi, A., Katzhendler, J., Haj-Yehie, A., and Sasson, S., Bioorg. Med. Chem., 2004, vol. 12, pp. 1183–1190. https://doi.org/10.1016/j.bmc.2003.11.025

    Article  CAS  PubMed  Google Scholar 

  14. Xia, N., Liu, T., Wang, Q., Xia, Q., and Bian, X., J. Microencapsul., 2017, vol. 34, pp. 571–581. https://doi.org/10.1080/02652048.2017.1367852

    Article  CAS  PubMed  Google Scholar 

  15. Olie, R.H., van der Meijden, P.E.J., Spronk, H.M.H., and ten Cate, H., Handbook Exp. Pharmacol., 2022, vol. 270, pp. 103–130. https://doi.org/10.1007/164_2020_357

    Article  CAS  Google Scholar 

  16. Suslina, Z.A., Erofeeva, A.V., Tanashyan, M.M., and Ionova, V.G., Neurolog. Psychiatry, 2011, vol. 19, pp. 562–573.

    Google Scholar 

  17. Lai, Y.S., Shih, C.Y., Huang, Y.F., and Chou, T.C., J. Agric. Food Chem., 2010, vol. 58, pp. 8596–8603. https://doi.org/10.1021/jf101518p

    Article  CAS  PubMed  Google Scholar 

  18. Shchelkonogov, V.A., Shipelova, A.V., Sinebryukhova, A.M., Shastina, N.S., Baranova, O.A., Chekanov, A.V., Solov’eva, E.Yu., and Fedin’ A.I., Biotechnology: Status and Development Prospects. Trudy Mezhdunarodnogo Kongressa (Proc. Int. Congress), Moscow, 2020, pp. 461–464. https://www.elibrary.ru/item.asp?selid=44375061&id=44374820

  19. Shchelkonogov, V.A., Sorokoumova, G.M., Baranova, O.A., Chekanov, A.V., Klochkova, A.V., Kazarinov, K.D., Solov’eva, E.Yu., Fedin, A.I., and Shvets, V.I., Biomed. Khim., 2016, vol. 62, pp. 577–583. https://doi.org/10.18097/PBMC20166205577

    Article  CAS  PubMed  Google Scholar 

  20. Shchelkonogov, V.A., Inshakova, A.M., Shipelova, A.V., Baranova, O.A., Chekanov, A.V., Shastina, N.S., Solov’eva, E.Yu., and Fedin, A.I., Mendeleev Commun., 2021, vol. 31, pp. 507–508. https://doi.org/10.1016/j.mencom.2021.07.023

    Article  CAS  Google Scholar 

  21. Farhana, A. and Lappin, S.L., Biochemistry, Lactate Dehydrogenase, StatPearls (Internet), 2022. https://www.ncbi.nlm.nih.gov/books/NBK557536

  22. Meroni, S.B., Riera, M.F., Pellizzari, E.H., Schteingart, H.F., and Cigorraga, S.B., Int. J. Androl., 2003, vol. 26, pp. 310–317. https://doi.org/10.1046/j.1365-2605.2003.00432.x

    Article  CAS  PubMed  Google Scholar 

  23. Awasthi, D., Nagarkoti, S., Sadaf, S., Chandra, T., Kumar, S., and Dikshit, M., Biochim. Biophys. Acta Mol. Basis Dis., 2019, vol. 1865, pp. 165542. https://doi.org/10.1016/j.bbadis.2019.165542

    Article  CAS  PubMed  Google Scholar 

  24. Jones, W., Li, X., Qu, Z., Perriott, L., Whitesell, R.R., and May, J.M., Free Radical Biol. Med., 2002, vol. 33, pp. 83–93. https://doi.org/10.1016/s0891-5849(02)00862-6

    Article  CAS  Google Scholar 

  25. Gomes, A., Fernandes, E., and Lima, J.C., J. Biochem. Biophys., 2005, vol. 65, pp. 48–80. Epub 2005 Nov 4. https://doi.org/10.1016/j.jbbm.2005.10.003

    Article  CAS  Google Scholar 

  26. Miyake, M., Kakizawa, Y., Tobori, N., Kurioka, M., Tabuchi, N., Kon, R., Shimokawa, N., Tsujino, Y., and Takagi, M., Colloids Surf. B, 2018, vol. 169, pp. 444–452. https://doi.org/10.13140/RG.2.1.3892.5280

    Article  CAS  Google Scholar 

  27. Mikheev, A.A., Shmendel’, E.V., Zhestovskaya, E.S., Nazarov, G.V., and Maslov, M.A., Tonkie Khim. Tekhnol., 2020, vol. 15, pp. 7–27. https://doi.org/10.32362/2410-6593-2020-15-1-7-27

    Article  CAS  Google Scholar 

  28. Eqbal, A., Ansari, V. A., Hafeez, A., Ahsan, F., Imran, M., and Tanweer, S., Res. J. Pharm. Technol., 2021, vol. 14, pp. 2852–2858. https://doi.org/10.52711/0974-360X.2021.00502

    Article  Google Scholar 

  29. Chekanov, A.V., Cand. Sci. (Biol.) Dissertation, Moscow, 2004.

Download references

ACKNOWLEDGMENTS

The authors express their gratitude to A.V. Romanenko for providing biomaterial for research, A.V. Symon for providing phosphatidylcholine Lipoid S-100, K.D. Kazarinov for providing arachidonic acid, as well as to the staff of the MIREA Center for Collective Use for providing equipment for research.

Funding

The work was carried out within the framework of state assignments for the RNRMU (no. 122051600109-5) and for the IRE RAS (no. 122041900109-3), and with financial support of the “Bazis” Foundation for the Development of Theoretical Physics and Mathematics (grant no. 22-1-1-28-1).

Author information

Authors and Affiliations

  1. MIREA—Russian Technological University (ITHT named after M.V. Lomonosov), 119571, Moscow, Russia

    V. A. Shchelkonogov, A. M. Inshakova, E. S. Darnotuk, A. V. Shipelova & N. S. Shastina

  2. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation (RNRMU), 117997, Moscow, Russia

    V. A. Shchelkonogov, A. V. Chekanov, O. A. Baranova, E. Yu. Solov’eva & A. I. Fedin

  3. Kotel’nikov Institute of Radioengineering and Electronics, Russian Academy of Sciences (IRE RAS), 141120, Fryazino, Russia

    V. A. Shchelkonogov, A. V. Chekanov & O. A. Baranova

Authors
  1. V. A. Shchelkonogov
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. M. Inshakova
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. E. S. Darnotuk
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. V. Shipelova
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. A. V. Chekanov
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. O. A. Baranova
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. N. S. Shastina
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. E. Yu. Solov’eva
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. A. I. Fedin
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by VAS, AMI, ESD, AVS, AVC, and NSS. Conceptualization: AVC; Methodology: AMI; Writing—original draft preparation: VAS; Writing—review and editing: AIF; Supervision: EYS. The first draft of the manuscript was written by OAB and NSS, and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to V. A. Shchelkonogov.

Ethics declarations

The data that support the findings of this study are available from the corresponding author upon reasonable request. The use of biomaterial (venous blood samples) obtained from a group of apparently healthy individuals in this work and its subsequent use by A.V. Romanenko in the work on the thesis “Features of Vascular Inflammation and Hemostasis in the Acute Period of Ischemic and Hemorrhagic Strokes” were approved by the Committee for Biomedical Ethics of the RNRMU (partial record of the minutes of the RNIMU no. 204 of February 1, 2021). All volunteers gave voluntary consent to taking biomaterial. No conflict of interest was declared by the authors.

Additional information

Publisher's Note. Pleiades Publishing remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Abbreviations: AA, arachidonic acid; ROS, reactive oxygen species; DHLA, dihydrolipoic acid; LDH, lactate dehydrogenase; LA, lipoic acid; LK2Hx, 1,6-di-O-lipoyloxyhexane; LA3Gro, 1,2,3-tri-O-lipoylglycerol; LADPAP, 2-O-lipoyloxy-1,3-(dipalmitoylamino)propane; PMNs, neutrophils; OG, oligoglycerol; PRP, platelet-rich plasma; LPO, lipid peroxidation; Pt, platelets; PBS, phosphate buffer solution (pH 7.4); PMA, phorbol-12-myristate-13-acetate; PC, phosphatidylcholine; DCFH-DA, 2,7-dichlorodihydrofluorescein diacetate; F-68, pluronic F-68.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Shchelkonogov, V.A., Inshakova, A.M., Darnotuk, E.S. et al. Effect of Nanodispersions with Lipoic Acid and Its Esters on the Functional Activity of Neutrophils and Platelets. Russ J Bioorg Chem 49, 1319–1327 (2023). https://doi.org/10.1134/S1068162023060122

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S1068162023060122

Keywords:

Search

Navigation