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Surface Effect of Iron Oxide Nanoparticles on the Suppression of Oxidative Burst in Cells

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Abstract

Overproduction of reactive oxygen species (ROS) is an unwanted phenomenon, leading to cellular damages. The aim of this study was to investigate the ability of neat and surface-modified iron oxide nanoparticles (IONs) to eliminate ROS produced by immune cells. The employed coating included heparin (ION@Hep) or heparin and chitosan grafted with phenolic compounds famous for antioxidant properties, i.e., gallic acid (ION@Ch-G) or phloroglucinol (ION@CH-P). A total peroxyl radical-trapping potential assay showed that both types of the phenolic compounds-modified IONs exhibited superior radical scavenging activity over the neat and ION@Hep particles at 100 μg/mL. Up to ~ 75 μg/mL, the particles were non-toxic towards RAW 264.7 macrophages. Capability of the particles to limit ROS production was investigated in vitro on polymorphonuclear (PMN) cells isolated from human whole blood and expressed as an ability to reduce the oxidative burst in the stimulated cells, as well as a potential to increase the viability of bacteria cultivated with the PMN cells. The highest viability of bacteria was observed for the neat and ION@Ch-G, while the ION@Ch-G particles also the most effectively inhibited the oxidative burst. The results indicated that ROS scavenging depend on the presence of polymer and selection of phenols, enriching the IONs.

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Data Availability

The data that support the findings of this study are available from the corresponding author, MŚ, upon reasonable request.

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Funding

This study was supported by the Czech Science Foundation No. 20-02177J. The Polish authors thank the EU Project POWR.03.02.00-00-I004/16.

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Authors and Affiliations

  1. Institute of Macromolecular Chemistry, Czech Academy of Sciences, Heyrovského Sq. 2, 162 06, Prague, Czech Republic

    Małgorzata Świętek, Kristýna Gunár, Olga Šebestová Janoušková & Daniel Horák

  2. Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387, Krakow, Poland

    Anna Kołodziej & Aleksandra Wesełucha-Birczyńska

  3. Institute of Physics, Czech Academy of Sciences, Cukrovarnická 10/112, 162 00, Prague, Czech Republic

    Pavel Veverka

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  1. Małgorzata Świętek
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Świętek, M., Gunár, K., Kołodziej, A. et al. Surface Effect of Iron Oxide Nanoparticles on the Suppression of Oxidative Burst in Cells. J Clust Sci 34, 323–334 (2023). https://doi.org/10.1007/s10876-022-02222-9

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