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Synthesis of New N-Benzoyl-N'-Triazine Thiourea Derivatives and Their Antibacterial Activity

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Abstract

A series of new N-benzoyl-N'-triazine thiourea derivatives have been synthesized via the reaction of 4-amino-6-methyl-3-thioxo-3,4-dihydro-1,2,4-triazin-5(2H)-one with benzoyl chloride derivatives and ammonium thiocyanate in acetone under reflux conditions. 4-Amino-6-methyl-3-thioxo-3,4-dihydro-1,2,4-triazin-5(2H)-one was prepared from the reaction of two equivalents of hydrazine hydrate with carbon disulfide and sodium pyruvate. The chemical structure of thioureas was confirmed using FT-IR, 1H NMR, 13C NMR, and high-resolution mass spectrometry, and elemental analysis. The synthesized thioureas were assayed for their antibacterial activity against both gram-positive (Micrococcusluteus and Bacilluscereus) and gram-negative (Pseudomonasaeruginosa and Escherichiacoli) bacteria using the agar well diffusion method.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Sciences, Tonekabon Branch, Islamic Azad University, 46841-61167, Tonekabon, Iran

    M. Marzi, K. Pourshamsian, F. Hatamjafari & A. R. Oliaey

  2. Young Researchers and Elite Club, East Tehran Branch, Islamic Azad University, 15847-43311, Tehran, Iran

    A. Shiroudi

Authors
  1. M. Marzi
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  2. K. Pourshamsian
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  3. F. Hatamjafari
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  4. A. Shiroudi
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  5. A. R. Oliaey
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Correspondence to K. Pourshamsian or A. Shiroudi.

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This article does not contain any studies involving human participants performed by any of the authors and does not contain any studies involving animals performed by any of the authors.

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The authors declare that they have no conflicts of interest.

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Corresponding author: e-mail: Kshams49@gmail.com (Kh. Pourshamsian); abolfazl.shiroudi@iauet.ac.ir (A. Shiroudi).

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Marzi, M., Pourshamsian, K., Hatamjafari, F. et al. Synthesis of New N-Benzoyl-N'-Triazine Thiourea Derivatives and Their Antibacterial Activity. Russ J Bioorg Chem 45, 391–397 (2019). https://doi.org/10.1134/S106816201905008X

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  • DOI: https://doi.org/10.1134/S106816201905008X

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