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Synthesis and In Vitro Antitumor Activity of Novel Chromenones Bearing Benzothiazole Moiety

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Abstract

6-(Benzo[d]thiazol-2-yl)-4-oxo-(4H)-chromene-3-carbaldehyde was utilized to construct a novel series of fused chromone bearing benzothiazole moiety, namely chromeno[2,3-b]azetol, benzo[c]chromene, and chromeno[2,3-c]pyrazole derivatives, as well as, non-fused chromones, such as thiazolidinone, pyrazolone, and pyridine derivatives. The in vitro antitumor activities of the synthesized products against six cancer cell lines, including A594, HCT-116, MCF-7, HepPG2, PC3, and HFB4, were evaluated. Some compounds exhibited significant anticancer activities against both lung and colon cancer cells very close to that of a standard drug doxorubicin.

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ACKNOWLEDGMENTS

Authors would like to express their deep appreciation and indebtedness to Chemistry Department, Faculty of Science, Ain Shams University, for their support of the work.

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Authors and Affiliations

  1. Chemistry Department, Faculty of Science, Ain Shams University, 11566, Abbasia, Cairo, Egypt

    Eman A. El-Helw, Hamed A. Derbala, Manal M. El-Shahawi & Marwa S. Salem

  2. Biochemistry Department, Division of Genetic Engineering and Biotechnology, National Research Centre, 12622, Dokki, Giza, Egypt

    Mamdouh M. Ali

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  1. Eman A. El-Helw
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The authors declare that they have no conflict of interest. This article does not contain any studies involving animals or human participants performed by any of the authors.

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Corresponding author: e-mail: marwa_k@sci.asu.edu.eg.

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Eman A. El-Helw, Derbala, H.A., El-Shahawi, M.M. et al. Synthesis and In Vitro Antitumor Activity of Novel Chromenones Bearing Benzothiazole Moiety. Russ J Bioorg Chem 45, 42–53 (2019). https://doi.org/10.1134/S1068162019010047

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