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Synthesis of paricalcitol: A novel strategy combining chemical and microbial transformations

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Abstract

A novel strategy was developed for the preparation of paricalcitol (1α,25-dihydroxy-19-norvitamin D2) via seven-step chemical transformation and one-step microbial transformation. Using vitamin D2 as a starting material, 1α- and 25-hydroxyl groups of paricalcitol were introduced by Pseudonocardia autotrophica CGMCC5098 at the late stage of the synthesis, allowing us to avoid harsh reaction conditions and tedious steps. The overall yield of paricalcitol was 0.75%.

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Authors and Affiliations

  1. Department of Сhemistry, School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, China

    J. Q. Luo, F. Jiang, W. Q. Song, W. Z. Fang & Q. Lu

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  1. J. Q. Luo
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  2. F. Jiang
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  3. W. Q. Song
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  4. W. Z. Fang
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  5. Q. Lu
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Correspondence to W. Z. Fang or Q. Lu.

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Luo, J.Q., Jiang, F., Song, W.Q. et al. Synthesis of paricalcitol: A novel strategy combining chemical and microbial transformations. Russ J Bioorg Chem 43, 323–327 (2017). https://doi.org/10.1134/S1068162017030104

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  • DOI: https://doi.org/10.1134/S1068162017030104

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