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Synthesis and antidepressant and anxiolytic activity of derivatives of pyrazolo[4,3-c]pyridine and 4-phenylhydrazinonicotinic acids

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Pharmaceutical Chemistry Journal Aims and scope

The synthesis of compounds effective in the treatment of anxiety—depression disorders is described. It is established that 4,6-dimethyl-2-(4-chlorophenyl)-2,3-dihydro-1H-pyrazolo[4,3-c]pyridine-3-one hydrochloride (IVa) possesses combined antidepressant and anxiolytic properties. Advantages of IVa are low toxicity and the absence of side effects typical of antidepressants (elevated anxiety) and benzodiazepine anxiolytics (myorelaxant and sedative action).

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Authors and Affiliations

  1. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia

    L. A. Zhmurenko, G. M. Molodavkin, T. A. Voronina & V. P. Lezina

Authors
  1. L. A. Zhmurenko
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  2. G. M. Molodavkin
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  3. T. A. Voronina
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  4. V. P. Lezina
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 46, No. 1, pp. 18 – 22, January, 2012.

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Zhmurenko, L.A., Molodavkin, G.M., Voronina, T.A. et al. Synthesis and antidepressant and anxiolytic activity of derivatives of pyrazolo[4,3-c]pyridine and 4-phenylhydrazinonicotinic acids. Pharm Chem J 46, 15–19 (2012). https://doi.org/10.1007/s11094-012-0726-z

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  • DOI: https://doi.org/10.1007/s11094-012-0726-z

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