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Prospects for the Development of an 225Ac/213Bi Generator Using Inorganic Hydroxide Sorbents

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Radiochemistry Aims and scope

Abstract

The ability of inorganic hydroxide sorbents Termoxid-5 (T-5) and Termoxid-39 (T-39) heat-treated at temperatures from 100 to 950°C to take up radionuclides of the 225Ac subfamily was examined in a wide range of solution acidities and salt compositions. T-5 and T-39 are principally suitable for the development of both direct and inverse 225Ac/213Bi generators with the activity of hundreds of millicuries of 225Ac.

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References

  1. Jurcic, J.G. et al., Blood, 2002, vol. 100, pp. 1233–1239.

    CAS  PubMed  Google Scholar 

  2. Miederer, M. et al., J. Nucl. Med., 2004, vol. 45, pp. 129–137.

    CAS  PubMed  Google Scholar 

  3. Allen, B.J. et al., Curr. Radiopharm., 2008, vol. 1, pp. 240–250.

    Article  CAS  Google Scholar 

  4. Allen, B.J., Phys. Med. Biol., 2007, vol. 52, pp. L15–L19.

    Article  CAS  PubMed  Google Scholar 

  5. Chérel, M. and Barbet, J., Alpha Emitting Radionuclides and Radiopharmaceuticals for Therapy: IAEA-TM-44 815, 2013.

    Google Scholar 

  6. Rosenblat, T.L. et al., Clin. Cancer Res., 2010, vol. 16, no. 21, pp. 5303–5311.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. https://doi.org/clinicaltrials.gov/.

  8. Apostolidis, C. et al., Anal. Chem., 2005, vol. 77, pp. 6288–6291.

    Article  CAS  PubMed  Google Scholar 

  9. Morgenstern, A., Bruchertseifer, F., and Apostolidis, C., Curr. Radiopharm., 2011, vol. 4, pp. 295–305.

    Article  CAS  PubMed  Google Scholar 

  10. Ermolaev, S.V., Zhuikov, B.L., Kokhanyuk, V.M., et al., Radiochim. Acta, 2012, vol. 100, pp. 1–7.

    Article  CAS  Google Scholar 

  11. Zhuikov, B.L., Kalmykov, S.N., Ermolaev, S.V., et al., Radiochemistry, 2011, vol. 53, no. 1, pp. 73–80.

    Article  CAS  Google Scholar 

  12. Aliev, R.A. et al., Solvent Extr. Ion Exch., 2014, vol. 32, no. 5, pp. 468–477.

    Article  CAS  Google Scholar 

  13. Weidner, J.W. et al., Appl. Radiat. Isot., 2012, vol. 70, no. 11, pp. 2602–2607.

    Article  CAS  PubMed  Google Scholar 

  14. Hoehr, C. et al., Phys. Procedia, 2017, vol. 90, pp. 200–208.

    Article  CAS  Google Scholar 

  15. Boll, R.A., Mirzadeh, S., Kennel, S.J., et al., J. Label. Compd. Radiopharm., 1997, vol. 40, p. 341.

    Google Scholar 

  16. McDevitt, M.R., Finn, R.D., Sgouros, G., et al., Appl. Radiat. Isot., 1999, vol. 50, no. 5, p. 895.

    Article  CAS  PubMed  Google Scholar 

  17. Bray, L.A., Tingey, J.M., DesChane, J.R., et al., Ind. Eng. Chem. Res., 2000, vol. 39, no. 9, p. 3189.

    Article  CAS  Google Scholar 

  18. Guseva, L.I. and Dogadkin, N.N., Radiochemistry, 2009, vol. 51, no. 2, pp. 169–174.

    Article  CAS  Google Scholar 

  19. Wu, C., Brechbiel, M.W., and Gansow, O.A., Radiochim. Acta, 1997, vol. 79, p. 141.

    CAS  Google Scholar 

  20. McAlister, D.R. and Horwitz, E.P., Appl. Radiat. Isot., 2009, vol. 67, no. 11, p. 1985.

    Article  CAS  PubMed  Google Scholar 

  21. Tsupko-Sitnikov, V.V., Actinium-225: radionuclide production and electromigration and nuclear spectroscopic studies, Cadn. Sci. (Chem.) Dissertation, Dubna, 1997.

    Google Scholar 

  22. Bray, L.A. and DesChane, J.R., Patent US 5 749 042, 1998.

  23. Ermolaev, S.V. and Skasyrskaya, A.K., Abstracts of Papers, VIII Vserossiiskaya konferentsiya po radiokhimii “Radiokhimiyia-2015” (VIII All-Russia Conf. on Radiochemistry “Radiochemistry-2015”), Zheleznogorsk, 2015, p. 442.

    Google Scholar 

  24. Morgenstern, A., Krolicki, L., Kunikowska, J., et al., J. Nucl. Med., 2014, vol. 55, suppl. 1, p. 390.

    Google Scholar 

  25. McDevitt, M.R. et al., Appl. Radiat. Isot., 1999, vol. 50, pp. 895–904.

    Article  CAS  PubMed  Google Scholar 

  26. Denisov, E.I. and Betenekov, N.D., Radiochemistry, 2018, vol. 60, no. 4, pp. 386–394.

    Article  CAS  Google Scholar 

  27. Lur’e, Yu.Yu., Spravochnik po analiticheskoi khimii (Handbook of Analytical Chemistry), Moscow: Khimiya, 1979, 5th ed.

    Google Scholar 

  28. Horwitz, E.P. and Bloomquist, C.A., J. Inorg. Nucl. Chem., 1975, vol. 37, pp. 425–434.

    Article  CAS  Google Scholar 

  29. Radionuclide transformations—energy and intensity of emissions, ICRP Publication 38, ICRP, 1983.

  30. Sharygin, L.M., Termostoikie neorganicheskie sorbenty (Heat-Resistant Inorganic Sorbents), Yekaterinburg: Ural’skoe Otdel. Ross. Akad. Nauk, 2012.

    Google Scholar 

  31. Puigdomenech, I., MEDUSA: Make Equilibrium Diagrams Using Sophisticated Algorithms, 2010.

    Google Scholar 

  32. Starik, I.E., Osnovy radiokhimii (Fundamentals of Radiochemistry), Moscow: Nauka, 1969.

    Google Scholar 

  33. Betenekov, N.D., Denisov, E.I., and Sharygin, L.M., Radiochemistry, 2016, vol. 58, no. 1, pp. 63–71.

    Article  CAS  Google Scholar 

  34. Denisov, E.I. and Betenekov, N.D., Radiochemistry, 2016, vol. 58, no. 6, pp. 631–639.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Yeltsin Ural Federal University, ul. Mira 19, Yekaterinburg, 620002, Russia

    N. D. Betenekov & E. I. Denisov

  2. Institute for Nuclear Research, Russian Academy of Sciences, pr. 60-letiya Oktyabrya 7a, Moscow, 117312, Russia

    A. N. Vasiliev, S. V. Ermolaev & B. L. Zhuikov

Authors
  1. N. D. Betenekov
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  2. E. I. Denisov
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  3. A. N. Vasiliev
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  4. S. V. Ermolaev
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  5. B. L. Zhuikov
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Correspondence to E. I. Denisov.

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Betenekov, N.D., Denisov, E.I., Vasiliev, A.N. et al. Prospects for the Development of an 225Ac/213Bi Generator Using Inorganic Hydroxide Sorbents. Radiochemistry 61, 211–219 (2019). https://doi.org/10.1134/S1066362219020140

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  • DOI: https://doi.org/10.1134/S1066362219020140

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