Abstract
Conditions were optimized for deuterium and tritium labeling of nicotine molecules applied onto a catalyst without using a solvent. Performing the reaction under these conditions at temperatures higher than 100°C leads to complete decomposition of nicotine molecules. Deuterium-labeled nicotine containing, on the average, 0.9 deuterium atom per molecule and tritium-labeled nicotine with a molar radioactivity of 10 Ci mmol−1 were prepared. The compound with the opened pyrrolidine ring is formed in the process as byproduct.
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Mineur, Y.S., Abizaid, A., Rao, Y., et al., Science, 2011, vol. 332, pp. 1330–1332.
Yoshida, T., Sakane, N., Umekawa, T., and Kondo, M., Physiol. Behav., 1994, vol. 55, no. 1, pp. 53–57.
Shigenaga, M.K., Jacob, P., Trevor, A., et al., J. Label. Compd. Radiopharm., 1987, vol. 24, no. 6, pp. 713–723.
Seeman, J.I., Secor, H.V., and Forrest, G., J. Label. Compd. Radiopharm., 1979, vol. 16, no. 3, pp. 387–395.
Jacob, P., III, Benowitz, N., and Shulgin, A.T., J. Label. Compd. Radiopharm., 1988, vol. 25, no. 10, pp. 1117–1128.
Shevchenko, V.P., Nagaev, I.Yu., and Myasoedov, N.F., J. Label. Compd. Radiopharm., 2010, vol. 53, nos. 11–12, pp. 693–703.
Ingold, C.K., Structure and Mechanism in Organic Chemistry, Ithaca: Cornell Univ. Press, 1969.
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Original Russian Text © V.P. Shevchenko, I.Yu. Nagaev, N.F. Myasoedov, 2015, published in Radiokhimiya, 2015, Vol. 57, No. 4, pp. 373–376.
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Shevchenko, V.P., Nagaev, I.Y. & Myasoedov, N.F. Preparation of deuterium- or tritium-labeled nicotine. Radiochemistry 57, 439–442 (2015). https://doi.org/10.1134/S1066362215040189
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DOI: https://doi.org/10.1134/S1066362215040189