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Nucleation and Growth Modeling of Protein Crystals in Capillaries

  • 26th INTERNATIONAL SYMPOSIUM “NANOSTRUCTURES: PHYSICS AND TECHNOLOGY”. NANOSTRUCTURE TECHNOLOGY
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Abstract

Within this work we model the spatial dependences of protein concentration, nucleation probability and the radius of lysozyme crystal in the experiments on capillary counter-diffusion crystallization. Within the model approach, we evaluate the conditions for the formation of lysozyme crystals with the target separation of 100 µm between centers of protein crystals. The predicted and observed number density, sizes and positions of protein crystals in capillary are in excellent agreement.

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ACKNOWLEDGMENTS

Authors thank the Ministry of Education and Science of the Russian Federation for financial support under the grant 14.587.21.0040 (project ID RFMEFI58717X0040).

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Authors and Affiliations

  1. St. Petersburg National Research University of Information Technologies, Mechanics, and Optics, St. Petersburg, Russia

    A. S. Sokolovskii, Yu. Berdnikov & V. G. Dubrovskii

  2. St. Petersburg National Research Academic University, Russian Academy of Sciences, St. Petersburg, Russia

    N. A. Besedina

Authors
  1. A. S. Sokolovskii
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  2. N. A. Besedina
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  3. Yu. Berdnikov
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  4. V. G. Dubrovskii
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Corresponding author

Correspondence to A. S. Sokolovskii.

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Sokolovskii, A.S., Besedina, N.A., Berdnikov, Y. et al. Nucleation and Growth Modeling of Protein Crystals in Capillaries. Semiconductors 52, 2132–2134 (2018). https://doi.org/10.1134/S1063782618160339

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  • DOI: https://doi.org/10.1134/S1063782618160339

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