Skip to main content
SpringerLink
Log in

Absolute Configuration of Andrographolide and Its Proliferation of Osteoblast Cell Lines

  • Structure of Organic Compounds
  • Published:
Crystallography Reports Aims and scope Submit manuscript

Abstract

Andrographolide, C20H30O5, is a labdane diterpenoid which was isolated from the leave of Andrographis paniculata. Its crystal structure is determined by single crystal X-ray diffraction: monoclinic, sp. gr. P21, Z = 2. Absolute configuration is determined by the refinement of the Flack parameter to 0.21(19). In the crystal, molecules are linked by O–H···O hydrogen bonds and C–H···O interactions into two dimensional network parallel to the (001) plane. Its proliferation of osteoblast cell lines is reported.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. J. A. Cauley, N. S. Wampler, J. M. Barnhart, et al., Osteoporos Int. 19, 1717 (2008).

    Article  Google Scholar 

  2. T. Paolucci, V. M. Saraceni, and G. Piccinini, J. Pain Res. 9, 177 (2016).

    Article  Google Scholar 

  3. P. Kulyal, U. K. Tiwari, and A. Shukla, Indian J. Chem. B 49, 356 (2010).

    Google Scholar 

  4. Bruker (y2009). APEX2, SAINT, and SADABS (Bruker AXS Inc., Madison, Wisconsin, USA, 2009).

    Google Scholar 

  5. G. M. Sheldrick, Acta Crystallogr. A 64, 112 (2008).

    Article  ADS  Google Scholar 

  6. A. L. Spek, Acta Crystallogr. D 65, 148 (2009).

    Article  Google Scholar 

  7. C. F. Macrae, P. R. Edginton, P. McCabe, et al., J. Appl. Crystallogr. 39, 453 (2006).

    Article  Google Scholar 

  8. F. H. Allen, O. Kennard, D. G. Watson, et al., J. Chem. Soc. Perkin Trans. 2, S1–S19 (1987).

    Article  Google Scholar 

  9. D. Cremer and J. A. Pople, J. Am. Chem. Soc. 97, 1354 (1975).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, Prince of Songkla University, Hat-Yai, Songkhla, 90112, Thailand

    S. Chantrapromma

  2. Department of Basic Science and Mathematics, Faculty of Science, Thaksin University, Songkhla, 90000, Thailand

    N. Boonnak

  3. Department of Biochemistry, Faculty of Science, Prince of Songkla University, Hat-Yai, Songkhla, 90112, Thailand

    T. Pitakpornpreecha & T. Yordthong

  4. Department of Engineering Chemistry, Vidya Vikas Institute of Engineering and Technology, Visvesvaraya Technological University, Alanahalli, Karnataka, Mysuru, 570028, India

    C. S. Chidan Kumar

  5. X-ray Crystallography Unit, School of Physics, Universiti Sains Malaysia, USM, Penang, 11800, Malaysia

    C. S. Chidan Kumar & H. K. Fun

Authors
  1. S. Chantrapromma
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. N. Boonnak
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. T. Pitakpornpreecha
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. T. Yordthong
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. C. S. Chidan Kumar
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. H. K. Fun
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to S. Chantrapromma.

Additional information

The article is published in the original.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Chantrapromma, S., Boonnak, N., Pitakpornpreecha, T. et al. Absolute Configuration of Andrographolide and Its Proliferation of Osteoblast Cell Lines. Crystallogr. Rep. 63, 412–417 (2018). https://doi.org/10.1134/S1063774518030069

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S1063774518030069

Search

Navigation