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On the structure of luminol sodium salts

  • Structure of Organic Compounds
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Abstract

The structures of Tamerit® (A) and Galavit® (B) pharmaceutical preparations have been solved by X-Ray single crystal and powder diffraction. These are luminol sodium salts possessing immunomodulatory and anti-inflammatory properties. It is shown that Tamerit® (A) is a hydrated salt, while Galavit® (B) is a mixture of two polymorphic modifications (B1 and B2) of anhydrous salt. Compound A is crystallized in a monoclinic system: a = 8.3429(4) Å, b = 22.0562(11) Å, c = 5.2825(2) Å, β = 99.893(3)°, V = 957.59(8) Å3, and Z = 4; sp. gr. P21/c. Compound B1 is crystallized in a monoclinic system: a = 14.7157(18), b = 3.7029(19), c = 16.0233(15) Å, β = 116.682(13)°, V = 780.1(4) Å3, and Z = 4; sp. gr. P21/c. Compound B2 is crystallized in an orthorhombic system: a = 27.7765(15) Å, b = 3.3980(19) Å, c = 8.1692(19) Å, V = 771.0(5) Å3, and Z = 4; sp. gr. Pna21. The absence of phase transitions between the B1 and B2 polymorphs has been established by differential scanning calorimetry.

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Authors and Affiliations

  1. Faculty of Chemistry, Moscow State University, Moscow, Russia

    V. B. Rybakov, V. V. Chernyshev & K. A. Paseshnichenko

  2. Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences, Leninskii pr. 31, Moscow, Russia

    V. V. Chernyshev

  3. State Research Center of the Russian Federation GNIIKhTEOS, Moscow, Russia

    V. D. Sheludyakov & P. A. Storozhenko

  4. State Research Center of the Russian Federation NIOPIK, Moscow, Russia

    N. G. Belyakov

  5. ZAO UK SVETOVIT, Moscow, Russia

    R. S. Boziev

  6. ZAO VITAFARM, Moscow, Russia

    V. N. Mochalov

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  1. V. B. Rybakov
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  2. V. V. Chernyshev
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  3. K. A. Paseshnichenko
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  4. V. D. Sheludyakov
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  5. N. G. Belyakov
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  7. V. N. Mochalov
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  8. P. A. Storozhenko
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Correspondence to V. B. Rybakov.

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Original Russian Text © V.B. Rybakov, V.V. Chernyshev, K.A. Paseshnichenko, V.D. Sheludyakov, N.G. Belyakov, R.S. Boziev, V.N. Mochalov, P.A. Storozhenko, 2014, published in Kristallografiya, 2014, Vol. 59, No. 3, pp. 427–437.

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Rybakov, V.B., Chernyshev, V.V., Paseshnichenko, K.A. et al. On the structure of luminol sodium salts. Crystallogr. Rep. 59, 383–393 (2014). https://doi.org/10.1134/S1063774514020187

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  • DOI: https://doi.org/10.1134/S1063774514020187

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