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The Rat Heart in the Prenatal and Postnatal Periods of Ontogenesis

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Abstract

Rats are the most common laboratory animals that are used in experiments to evaluate the cardiotoxic and, particularly, teratogenic effects of therapeutic agents. For correct interpretation of results of experimental studies, it is necessary to have a detailed understanding of the specific features of the development and structure of the heart of laboratory animals. The cardiac morphogenesis in rats, compared with that of humans, has the following specific features: (1) the peak of proliferative activity of cardiomyocytes occurs in the late stages of the prenatal period of ontogenesis, (2) the transition of the myocardium from hyperplastic to hypertrophic growth occurs in the early postnatal period of ontogenesis, and (3) the hypertrophic type of myocardial growth consists in the formation of cardiomyocytes with several diploid nuclei (multinucleated cardiomyocytes).

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  1. Siberian State Medical University, 634050, Tomsk, Russia

    V. V. Ivanova, I. V. Milto, O. N. Serebrjakova & I. V. Sukhodolo

  2. Seversk Biophysical Research Centre, 636013, Seversk-13, Russia

    I. V. Milto

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I.V. Milto developed the concept of this paper and also carried out a critical analysis of the content of the literature review. О.N. Serebrjakova participated in the writing of the “Development of the Rat’s Heart in the Prenatal Period of Ontogenesis” section. V.V. Ivanova participated in the writing of the “Development of the Rat’s Heart in the Postnatal Period of Ontogenesis” section, preparing the manuscript for publication, and is also the author of illustrations. I.V. Sukhodolo approved the final version of the article for publication.

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Correspondence to V. V. Ivanova.

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The authors declare that they have no conflict of interests.

This article does not contain any studies involving human participants or laboratory animals as experimental models performed by the authors.

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Translated by A. Ermakov

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Ivanova, V.V., Milto, I.V., Serebrjakova, O.N. et al. The Rat Heart in the Prenatal and Postnatal Periods of Ontogenesis. Russ J Dev Biol 52, 287–300 (2021). https://doi.org/10.1134/S1062360421050039

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  • DOI: https://doi.org/10.1134/S1062360421050039

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