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The Effect of a Lipid Extract from the Marine Green Algae Codium fragile (Suringar) Hariot 1889 on Metabolic Reactions under Acute Stress

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Abstract

The effect of a lipid extract isolated from the marine green algae Codium fragile (Suringar) Hariot on the liver and blood biochemical indicators in mice under the impact of acute stress (vertical fixation by the dorsal neck fold) was studied. The pharmacological effect of the C. fragile lipid extract was manifested in the restoration of lipid and carbohydrate metabolism, as well as in the normalization of the indicators of the endogenous antioxidant defense system under the effect of stress. The biological activity of the lipid extract of C. fragile is, probably, due to the action of its constituent polyunsaturated fatty acids of the ω-3 and ω-6 families. The lipid extract of C. fragile was not inferior to the reference Omega-3 preparation in restoring the body’s metabolic reactions caused by the impact of the stress; however, it showed higher antioxidant activity.

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Funding

This work was carried out within the framework of a State Assignment of the Ilyichev Pacific Oceanological Institute (Far Eastern Branch of the Russian Academy of Sciences) on the topic “Ecological and Biogeochemical Processes in Marine Ecosystems: The Role of Natural and Anthropogenic Factors,” project no. 0211-2021-0014, registration no. 121-21500052-9.

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  1. Il’ichev Pacific Oceanological Institute, Far East Branch, Russian Academy of Sciences, 690041, Vladivostok, Russia

    S. E. Fomenko, N. F. Kushnerova, V. G. Sprygin, E. S. Drugova, L. N. Lesnikova & V. Yu. Merzlyakov

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  1. S. E. Fomenko
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  2. N. F. Kushnerova
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  3. V. G. Sprygin
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Correspondence to S. E. Fomenko.

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ETHICS APPROVAL AND CONSENT TO PARTICIPATE

The experiments with animals were conducted in compliance with the NIH Guidelines for the care and use of laboratory animals (http://oacu.od.nih.gov/regs/index.htm). Experimental protocols were approved by the Ethics Committee of Ilyichev Pacific Oceanological Institute (Protocol No. 21 of November 10, 2022).

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Fomenko, S.E., Kushnerova, N.F., Sprygin, V.G. et al. The Effect of a Lipid Extract from the Marine Green Algae Codium fragile (Suringar) Hariot 1889 on Metabolic Reactions under Acute Stress. Biol Bull Russ Acad Sci 51, 260–270 (2024). https://doi.org/10.1134/S1062359023602690

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