Abstract
A new voltammetric approach was developed for the determination of paracetamol in tablet and syrup samples using chemometric optimization. The method is based on the use of the gold nanoparticles–polyaniline (AuNPs−PA) modified pencil graphite electrode (PGE). Electrode system was fabricated by using the electrochemical reduction of gold on aniline modified pencil electrode to give gold nanoparticles. A 33 full factorial design was used to find optimal oxidation conditions of paracetamol on the AuNPs−PA−PGE. The optimal oxidation conditions of drug substance were found as –524 mV for the accumulation potential, 295 s for the accumulation time and pH 8.69 (for the phosphate buffer solution, 0.1 M). The determination of paracetamol was linear in the range of 2.0 × 10–7–6.0 × 10–6 M with a detection limit of 5 × 10–8 M. As a result, the proposed voltammetric approach gave satisfactory results for the determination of the related drug substance in tablets and syrup.
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ACKNOWLEDGMENTS
This work was done within the Chemometric Laboratory of Faculty of Pharmacy and it was supported by the scientific research project no. 10A3336001 of Ankara University.
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Remziye Güzel, Ekşi, H., Dinç, E. et al. New Voltammetric Approach to the Quantitation of Paracetamol in Tablets and Syrup using Chemometric Optimization Technique. J Anal Chem 74, 296–305 (2019). https://doi.org/10.1134/S1061934819030110
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DOI: https://doi.org/10.1134/S1061934819030110