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Clinical and Genetic Characteristics of Congenital Long QT Syndrome

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Abstract

Long QT syndrome is a rare ion channel cardiac disorder, the main manifestations of which are prolongation of the QT interval on the ECG and ventricular arrhythmias, which can cause sudden cardiac death at a young age. Diagnosis and treatment of this syndrome is an urgent problem, since the disease is heterogeneous and effective therapy requires molecular genetic diagnosis to accurately determine the type of this pathology. This review discusses clinical and genetic characteristics of different types of congenital long QT syndrome.

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Funding

This study was supported by the Russian Ministry of Science and Higher Education (Federal Scientific and Technical Program for the Development of Genetic Technologies for 2019–2027, contract no. 075-15-2021-1061, RF 193021X0029).

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Authors and Affiliations

  1. Research Institute of Medical Genetics, Tomsk National Research Medical Center, Russian Academy of Sciences, 634050, Tomsk, Russia

    A. E. Postrigan, N. P. Babushkina & N. A. Skryabin

  2. Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, 634012, Tomsk, Russia

    L. I. Svintsova & I. V. Plotnikova

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  1. A. E. Postrigan
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Correspondence to A. E. Postrigan.

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Postrigan, A.E., Babushkina, N.P., Svintsova, L.I. et al. Clinical and Genetic Characteristics of Congenital Long QT Syndrome. Russ J Genet 58, 1216–1227 (2022). https://doi.org/10.1134/S1022795422100064

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  • DOI: https://doi.org/10.1134/S1022795422100064

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