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Polymorphism of the Interleukin Genes IL-17A G197A and IL-17F A7488G in Patients with Gastric Cancer in the West Siberian Region

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Abstract

The frequency of occurrence of alleles of the IL-17A G197A and IL-17F A7488G genes in 150 people with gastric cancer and 103 healthy people was analyzed. The frequencies of genotypes IL-17F A7488G in patients (AA—68.6, AG—25.3, and GG—6%) did not differ significantly from those in the control (AA—77.7, AG—22.3, and GG—0.0%). Carriers of the GG genotype were found only in patients. There were no significant differences between patients and healthy people (χ2 = 4.80, p < 0.09). The frequencies of genotypes IL-17A G197A in patients (GG—10.6, AG—48.7, and AA—40.7%) differed from the control (GG—11.7, AG—70.8, and AA—17.5%). The distribution of IL-17A genotypes G197A “case–control” showed that the frequency of occurrence of the AA genotype in a sample of patients with gastric cancer is two times higher than in a sample of healthy people. Significant differences between patients and healthy people were revealed (χ2 = 15.79, p < 0.0003). Significant differences were found between sick and healthy women both in IL-17A G197A (χ2 = 16.18, p < 0.0003) and in IL-17F A488G (χ2 = 7.176, p < 0.027). No significant differences were found between the male samples. The results of our studies showed that only the A allele and the AA genotype of the IL-17A G197A gene are significantly more common in patients with gastric cancer than in healthy people, which may be a marker of the risk of developing gastric cancer in people living in the West Siberian region. Haplotypes characteristic only of patients with gastric cancer were identified. One of them (AAGG) is found with the same frequency in both men and women, and the second (AGGG) is most characteristic of women.

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Funding

This work was carried out with the financial support of the Budget Project FWNR 2022-0021.

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Authors and Affiliations

  1. Federal Research Center, Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, 630090, Novosibirsk, Russia

    M. A. Gubina & V. N. Babenko

  2. Novosibirsk State Pedagogical University, 630126, Novosibirsk, Russia

    I. G. Solovieva

  3. City Clinical Hospital No. 1, 630091, Novosibirsk, Russia

    A. V. Sokolov

  4. Sechenov First Moscow State Medical University, 119991, Moscow, Russia

    E. Yu. Gubina

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  1. M. A. Gubina
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Gubina, M.A., Solovieva, I.G., Babenko, V.N. et al. Polymorphism of the Interleukin Genes IL-17A G197A and IL-17F A7488G in Patients with Gastric Cancer in the West Siberian Region. Russ J Genet 58, 823–828 (2022). https://doi.org/10.1134/S1022795422070067

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