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Association between Allelic Variants of IL2, IL2RA, and IL7R Genes and Multiple Sclerosis

  • HUMAN GENETICS
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Abstract

Multiple sclerosis is a chronic progressive disease of nervous system caused by a combination of genetic and environmental factors leading to the development of a complex of autoimmune and neurodegenerative processes. We performed the analysis of association between multiple sclerosis and polymorphic markers of interleukin-2 (IL2), interleukin-2 receptor alpha chain (IL2A) and interleukin-7 receptor alpha chain (IL7R) in the group of Russians, Tatars, and Bashkirs from the Republic of Bashkortostan (N = 1620). In the total study group, we detected the association of IL7R rs10624573*I (OR = 0.79, PBonf = 0.018) and rs1494558*T (OR = 1.44, PBonf = 2.33 × 10–4) variants with multiple sclerosis. When analyzed separately according to the ethnic origin, the association with IL7R rs1494558*T (OR = 1.49, PBonf = 0.005) remained significant in the group of Russians, and the association of IL7R rs10624573*I remained significant in the group of Bashkirs (OR = 0.56, PBonf = 0.02). We performed the multilocus analysis of association using the APSampler algorithm, and found seven combinations of the alleles and/or genotypes of the studied polymorphic loci, significantly associated with multiple sclerosis, most frequently including IL7R rs1494558 and IL7R rs10624573 allelic variants.

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Authors and Affiliations

  1. Institute of Biochemistry and Genetics, Ufa Federal Research Centre, Russian Academy of Sciences, 450054, Ufa, Russia

    Y. R. Timasheva, O. V. Zaplakhova, T. R. Nasibullin, I. A. Tuktarova, V. V. Erdman & O. E. Mustafina

  2. Department of Medical Genetics and Fundamental Medicine, Bashkir State Medical University, 450000, Ufa, Russia

    Y. R. Timasheva, O. V. Zaplakhova & K. Z. Bakhtiiarova

  3. Department of Genetics and Fundamental Medicine, Bashkir State University, 450076, Ufa, Russia

    O. E. Mustafina

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  1. Y. R. Timasheva
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Statement of compliance with standards of research involving humans as subjects. The study was performed in accordance with the ethical principles of medical research involving human subjects enshrined in the Declaration of Helsinki (2013). Written informed voluntary consent was obtained from each study participant.

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Timasheva, Y.R., Zaplakhova, O.V., Nasibullin, T.R. et al. Association between Allelic Variants of IL2, IL2RA, and IL7R Genes and Multiple Sclerosis. Russ J Genet 55, 487–494 (2019). https://doi.org/10.1134/S1022795419030153

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