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Polymeric Carriers of Insulin

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Abstract—

The possibility of creating acid-stable polymeric insulin carriers capable of swelling in a weakly alkaline medium and being adsorbed on the intestinal walls with insulin release has been studied. In vitro and in vivo experiments have shown that the optimal carrier is a gastric-insoluble polymer capsule containing a hydrogel based on a copolymer of acrylamide and acrylic acid modified by a compound that inhibits the enzymes of the small intestine and provides an enhanced mucoadhesive hydrogel.

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ACKNOWLEDGMENTS

We express our sincere thanks to L.K. Staroseltsev for invaluable assistance in animal testing.

Funding

This work was performed in the framework of the State Mission of the Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences.

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Authors and Affiliations

  1. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences, 119991, Moscow, Russia

    I. L. Valuev, I. V. Obydennova, L. V. Vanchugova & L. I. Valuev

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  1. I. L. Valuev
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  2. I. V. Obydennova
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  3. L. V. Vanchugova
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  4. L. I. Valuev
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Correspondence to I. L. Valuev.

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Valuev, I.L., Obydennova, I.V., Vanchugova, L.V. et al. Polymeric Carriers of Insulin. Polym. Sci. Ser. A 61, 292–295 (2019). https://doi.org/10.1134/S0965545X19030192

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  • DOI: https://doi.org/10.1134/S0965545X19030192

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