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Morphometric and Functional Changes of the Brain in Mental Disorders and Their Dynamics during Drug Treatment

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Abstract

This review examines the results of morphometric studies of the brain in recent years, devoted to the influence of neurodegenerative changes (negative neuroplasticity) on the pathogenesis of major mental diseases: major depressive disorder and schizophrenia. Modern ideas about functional changes in the brain in these diseases are also considered. The relationship between the main groups of psychotropic drugs were analyzed: antidepressants, neuroleptics, and neuroprotectors with the detected morphometric changes.

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Funding

The study was carried out in accordance with the topic “Mechanisms of the Formation of Physiological Functions in Phylo- and Ontogenesis and the Influence of Endogenous and Exogenous Factors on Them.” State order no. АААА-А18-118012290373-7.

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Authors and Affiliations

  1. Bekhterev National Medical Research Center of Psychiatry and Neurology Ministry of Heath of the Russian Federation, St. Petersburg, Russia

    I. V. Galanin, A. G. Naryshkin, I. Yu. Liaskina & T. A. Skoromets

  2. Pavlov First St. Petersburg State Medical University, St. Petersburg, Russia

    T. A. Skoromets

  3. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia

    A. G. Naryshkin

  4. Mechnikov Northwest State Medical University, St. Petersburg, Russia

    A. G. Naryshkin

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  1. I. V. Galanin
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  2. A. G. Naryshkin
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  3. I. Yu. Liaskina
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  4. T. A. Skoromets
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Correspondence to A. G. Naryshkin.

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Galanin, I.V., Naryshkin, A.G., Liaskina, I.Y. et al. Morphometric and Functional Changes of the Brain in Mental Disorders and Their Dynamics during Drug Treatment. Hum Physiol 48, 306–312 (2022). https://doi.org/10.1134/S0362119722020062

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  • DOI: https://doi.org/10.1134/S0362119722020062

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