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A selective sorbent for removing bacterial endotoxins from blood

  • Physical Chemistry of Surface Phenomena
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Abstract

Synthetic ligands carrying a positive charge and capable of selective binding of bacterial endotoxins are covalently immobilized on surfaces of domestic hemosorbent Styrosorb-514 based on hypercrosslinked polystyrene. It is shown that the resulting sorbent aimed at treating sepsis exceeds imported specific hemosorbent in Toraymyxin™ columns in removing lipopolysaccharides, and can be used in domestically-produced Desepta columns.

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References

  1. D. C. Angus, W. T. Linde-Zwirble, J. Lidicker, et al., Crit. Care Med. 29, 1303 (2001).

    Article  CAS  Google Scholar 

  2. H. Burchardi and H. Schneide., Pharmacoeconomics 22, 793 (2004).

    Article  Google Scholar 

  3. V. A. Voinov, Efferent Therapy of Critical States in Reanimatology (PSPbGMU, St. Petersburg, 2013) [in Russian].

    Google Scholar 

  4. G. Kumar, N. Kumar, A. Taneja, et al., Chest 140, 1223 (2011).

    Article  Google Scholar 

  5. J. L. Vincent, J. Rello, J. Marshall, et al., J. Am. Med. Assoc. 302, 2323 (2009).

    Article  CAS  Google Scholar 

  6. F. Vidal, J. Mensa, M. Almera, et al., Arch. Int. Med. 156, 2121 (1996).

    Article  CAS  Google Scholar 

  7. V. M. Ranieri, B. T. Thompson, P. S. Barie, et al., N. Engl. J. Med. 366, 2055 (2012).

    Article  CAS  Google Scholar 

  8. S. M. Opal, G. E. Garber, S. P. LaRosa, et al., Clin. Infect. Dis. 37, 50 (2003).

    Article  CAS  Google Scholar 

  9. E. Abraham, K. Reinhart, S. Opal, et al., J. Am. Med. Assoc. 290, 238 (2003).

    Article  CAS  Google Scholar 

  10. C. A. Derek and T. van der Pol., N. Engl. J. Med. 369, 840 (2013).

    Article  Google Scholar 

  11. P. R. Dellinger, M. M. Levy, A. Rhodes, et al., Crit. Care Med. 41, 580 (2013).

    Article  Google Scholar 

  12. B. G. Stegmay., Blood Purif. 14, 94 (1996).

    Article  Google Scholar 

  13. B. G. Stegmay., Blood Purif. 18, 149 (2000).

    Article  Google Scholar 

  14. T. Rimmelé and J. A. Kellu., Crit. Care 15, 205 (2011).

    Article  Google Scholar 

  15. B. Davies and J. Cohe., Lancet Infect Dis. 11, 65 (2011).

    Article  CAS  Google Scholar 

  16. M. Antonelli, M. Ranieri, C. Ronco, et al., Web-based Collaborative Data Collection Project Progetto EUPHAS 2 (TM07). http://www.euphas2.eu/downloads/1-EU2_study_protocol_RevOct10.pdf.

  17. www.altecomedical.com/the_alteco_lps_adsorber/the_product/.

  18. www.gambro.com/en/global/Products/Acute-Care/Hemofilter-Sets/Oxiris/.

  19. V. N. Gapanovich, V. V. Kirkovskii, D. S. Tret’yak, et al., Voen. Med., No. 3, 98 (2012).

    Google Scholar 

  20. V. N. Gapanovich, V. V. Kirkovskii, D. S. Tret’yak, et al., Voen. Med., No. 2, 95 (2013).

    Google Scholar 

  21. V. A. Davankov and M. P. Tsyurupa, Hypercrosslinked Polymeric Networks and Adsorbing Materials, Synthesis, Structure, Properties and Application (Elsevier, New York, 2010).

    Google Scholar 

  22. V. A. Davankov, M. P. Tsyurupa, and L. A. Pavlova, Immunopathogenesis of Sepsis and Use of the Hemosorption for Treatment of Cancer Patients with Sepsis, Ed. by N. Yu. Anisimova (Nova Publ., New York, 2014), p.57.

  23. R. A. Malinauska., Artif. Organs 21, 1255 (1997).

    Article  Google Scholar 

  24. www.gemos.ru/products/29/99/.

  25. N. Yu. Anisimova, V. A. Davankov, M. I. Budnik, et al., Ross. Bioterap. Zh. 9 (4), 113 (2010).

    CAS  Google Scholar 

  26. M. Vaara, in Handbook of Endotoxin, Ed. by M. Vaara, H. Nikaido (Elsevier, Amsterdam, 1984), p.1.

  27. F. B. Anspach, J. Biochem. Biophys. Methods 49, 665 (2001).

    Article  CAS  Google Scholar 

  28. P. O. Magalhaes, A. M. Lopes, P. G. Mazzola, et al., J. Pharm. Pharmaceut. Sci. 10, 388 (2007).

    Google Scholar 

  29. A. P. Moran, E. T. Rietschel, T. U. Kosunen, and U. Zahringer, J. Bacteriol. 173, 618 (1991).

    Article  CAS  Google Scholar 

  30. M. Caroff and D. Karibia., Carbohydr. Res. 338, 2431 (2003).

    Article  CAS  Google Scholar 

  31. A. Bergstrand, C. Svanberg, M. Langton, and M. Nyde., Colloids Surf. B: Biointerfaces 53, 9 (2006).

    Article  CAS  Google Scholar 

  32. J. C. Marshall et al., Crit. Care 6, 342 (2002).

    Article  Google Scholar 

  33. Sh. Hisataka, M. Masahiro, S. Yoshitada, et al., Jpn. J. Artif. Organs 22, 204 (1993).

    Google Scholar 

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Authors and Affiliations

  1. Bauman State Technical University, Moscow, 105005, Russia

    A. S. Morozov, M. N. Kopitsyna, I. V. Bessonov, N. V. Karelina & A. V. Nuzhdina

  2. NPP Biotekh-M OOO, Moscow, 123181, Russia

    I. Yu. Sarkisov

  3. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Moscow, 119991, Russia

    L. A. Pavlova, M. P. Tsyurupa, Z. K. Blinnikova & V. A. Davankov

Authors
  1. A. S. Morozov
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  2. M. N. Kopitsyna
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  3. I. V. Bessonov
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  4. N. V. Karelina
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  5. A. V. Nuzhdina
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  6. I. Yu. Sarkisov
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  7. L. A. Pavlova
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  8. M. P. Tsyurupa
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  9. Z. K. Blinnikova
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  10. V. A. Davankov
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Corresponding author

Correspondence to V. A. Davankov.

Additional information

Original Russian Text © A.S. Morozov, M.N. Kopitsyna, I.V. Bessonov, N.V. Karelina, A.V. Nuzhdina, I.Yu. Sarkisov, L.A. Pavlova, M.P. Tsyurupa, Z.K. Blinnikova, V.A. Davankov, 2016, published in Zhurnal Fizicheskoi Khimii, 2016, Vol. 90, No. 12, pp. 1876–1882.

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Morozov, A.S., Kopitsyna, M.N., Bessonov, I.V. et al. A selective sorbent for removing bacterial endotoxins from blood. Russ. J. Phys. Chem. 90, 2465–2470 (2016). https://doi.org/10.1134/S0036024416120165

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  • DOI: https://doi.org/10.1134/S0036024416120165

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