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Experimental Setup Based on a Quantum Cascade Laser Tunable in the Wavelength Range of 5.3–12.8 µm for Spectral Analysis of Human Exhaled Air

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Abstract

An experimental setup and a method for analyzing multicomponent gas mixtures, including human-exhaled air, have been presented. The installation consists of a quantum cascade laser that is tunable in the wavelength range of 5.3–12.8 µm and has a peak power of 150 mW and a multi-pass Herriot gas cell that allows obtaining an optical path of up to 76 m. The registration time of a single spectrum is about 50 ms. For acetone and ethanol which are potential biomarkers of some human diseases the sensitivity threshold at the sub-ppm level has been experimentally determined. A system of sample preparation and pre-drying that allows analyzing both multicomponent gas mixtures and the air exhaled by a person has been proposed. The variants of application of the described installation in biomedical applications has been proposed.

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Funding

The work was supported by RFBR grant 18-29-02024.

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Authors and Affiliations

  1. Bauman Moscow State Technical University, Moscow, Russia

    A. V. Shcherbakova, D. R. Anfimov, I. L. Fufurin, I. S. Golyak, I. A. Trapeznikova, E. R. Kareva & A. N. Morozov

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  1. A. V. Shcherbakova
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  2. D. R. Anfimov
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  3. I. L. Fufurin
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Correspondence to A. V. Shcherbakova.

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Translated by N. Petrov

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Shcherbakova, A.V., Anfimov, D.R., Fufurin, I.L. et al. Experimental Setup Based on a Quantum Cascade Laser Tunable in the Wavelength Range of 5.3–12.8 µm for Spectral Analysis of Human Exhaled Air. Opt. Spectrosc. 129, 830–837 (2021). https://doi.org/10.1134/S0030400X21060151

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