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Association of SLC18A1, TPH1, and RELN gene polymorphisms with risk of paranoid schizophrenia

  • Genomics. Transcriptomics
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Abstract

A biochip was developed to examine the polymorphisms of genes associated with schizophrenia risk, including DISC1, RELN, ZNF804A, PLXNA2, COMT, SLC18A1, CACNA1C, ANK2, TPH1, PLAA, and SNAP-25. Allele and genotype frequencies of the genes were determined in 198 schizophrenics and 192 healthy subjects from Bashkortostan (ethnic Russians and Tatars). The frequencies of allele A (p = 0.007) and genotype AA (p = 0.002) of the rs2270641 A>C polymorphism of SLC18A1 in the patients with paranoid schizophrenia was lower than in the healthy subjects. The frequency of genotype AA of the rs1800532 C>A polymorphism of TPH1 in the schizophrenics was higher than in the healthy subjects (p = 0.036). Compared with the healthy subjects, the ethnic Tatar patients with paranoid schizophrenia had a lower frequency of allele C of the rs7341475 C>T polymorphism of RELN (p = 0.039) and a higher frequency of genotype AA of the rs1800532 C>A polymorphism of TPH1 (p = 0.019, OR = 2.52, CI 1.18-5.38). The frequency of allele C (p = 0.0001) and genotype GC (p = 0.0001) of the rs1327175 G>C polymorphism of PLXNA2 was elevated in the patients with a family history of paranoid schizophrenia. Based on the results, the SLC18A1, TPH1, and RELN polymorphisms were associated with risk of schizophrenia.

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Abbreviations

SNP:

single nucleotide polymorphism

CNV:

copy number variation

DISC1 :

disrupted in schizophrenia 1 gene

RELN:

reelin

ZNF804A:

zinc-finger protein 804A

PLXNA2:

plexin A2

COMT:

catechol-O-methyltransferase

SLC18A1:

vesicular monoamine transporter 1

CACNA1C:

voltage-dependent L-type calcium channel α-1C subunit

ANK3:

ankyrin 3

TPH1:

tryptophan hydroxylase 1

PLAA:

phospholipase A2-activating protein

SNAP-25:

synaptosome-associated protein 25

PCR:

polymerase chain reaction

RFLP:

restriction fragment length polymorphism

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Authors and Affiliations

  1. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991, Russia

    D. Yu. Galaktionova & T. V. Nasedkina

  2. Institute of Biochemistry and Genetics, Ufa Research Center, Russian Academy of Sciences, Ufa, 450054, Russia

    A. E. Gareeva & E. K. Khusnutdinova

  3. Dmitrii Rogachev Research and Clinical Center of Children’s Hematology, Oncology, and Immunology, Moscow, 117997, Russia

    T. V. Nasedkina

Authors
  1. D. Yu. Galaktionova
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  2. A. E. Gareeva
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  3. E. K. Khusnutdinova
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  4. T. V. Nasedkina
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Correspondence to T. V. Nasedkina.

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Original Russian Text © D.Yu. Galaktionova, A.E. Gareeva, E.K. Khusnutdinova, T.V. Nasedkina, 2014, published in Molekulyarnaya Biologiya, 2014, Vol. 48, No. 4, pp. 629–639.

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Galaktionova, D.Y., Gareeva, A.E., Khusnutdinova, E.K. et al. Association of SLC18A1, TPH1, and RELN gene polymorphisms with risk of paranoid schizophrenia. Mol Biol 48, 546–555 (2014). https://doi.org/10.1134/S0026893314030042

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  • DOI: https://doi.org/10.1134/S0026893314030042

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