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The Effect of Astaxanthin on the Functional State of Brain Mitochondria in Rats with Heart Failure

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Abstract

The effect of astaxanthin on the functional state of brain mitochondria in rats with heart failure was studied. Heart failure was achieved by administering isoproterenol to rats subcutaneously. Chronic administration of astaxanthin was carried out orally. It was found that the injection of isoproterenol impaired the functional state of the mitochondria of the rat brain, while the administration of astaxanthin canceled the effect of isoproterenol and improved the functional state of mitochondria in rats with heart failure. At the same time, the respiratory control of rat brain mitochondria increased. The content of the main subunits, such as the alpha subunit of complex V, the mitochondrially encoded cytochrome c oxidase I of complex IV, the assembly factor of the ubiquinone oxidoreductase 8 complex of complex I, succinate dehydrogenase complex II, and cytochrome b-c1 complex of subunit 2 of complex III increased. Isoproterenol accelerated Ca2+‑induced mitochondrial swelling, while astaxanthin reduced this parameter. Astaxanthin had a protective effect on mitochondria.

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ACKNOWLEDGMENTS

The scientific equipment of the Center for Collective Use of ITEB RAS was used in the work.

Funding

The work was carried out with the financial support of the Russian Foundation for Basic Research, projects no. 20-04-00131 and no. 20-015-00072, as well as State Assignment no. 075-01027-22-00.

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Authors and Affiliations

  1. Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, 142290, Pushchino, Moscow oblast, Russia

    R. R. Krestinin, Yu. L. Baburina, I. V. Odinokova, L. D. Sotnikova & O. V. Krestinina

Authors
  1. R. R. Krestinin
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  2. Yu. L. Baburina
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  3. I. V. Odinokova
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  4. L. D. Sotnikova
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  5. O. V. Krestinina
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Corresponding author

Correspondence to O. V. Krestinina.

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CONFLICT OF INTEREST

The authors declare that they have no conflicts of interest.

COMPLIANCE WITH ETHICAL STANDARDS

The experiments were carried out in accordance with the Regulations on Conducting Research on Experimental Animals (Order no. 755 of the Ministry of Health of the Russian Federation dated August 12, 1997). The Protocol was approved by the Commission on Biological Safety and Ethics of the Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences (Protocol no. 05/2022 of March 05, 2022).

Additional information

Translated by E. Puchkov

Abbreviations: ISO, isoproterenol; RBM, rat brain mitochondria; LDH, lactate dehydrogenase; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; MTCO1, mitochondrially encoded cytochrome c oxidase I of complex IV; CIII-UQCRC2, cytochrome b-c1 complex of subunit 2 of complex III; RC, respiratory control.

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Krestinin, R.R., Baburina, Y.L., Odinokova, I.V. et al. The Effect of Astaxanthin on the Functional State of Brain Mitochondria in Rats with Heart Failure. BIOPHYSICS 67, 744–751 (2022). https://doi.org/10.1134/S0006350922050104

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