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Inhibitory Effect of Aqueous Extract from Yerba Mate (Ilex paraguariensis) on the Process of Lipid Peroxidation of Liposomal Membranes

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Abstract

The effect of aqueous extract from yerba mate (Ilex paraguariensis) on Fe2+-induced lipid peroxidation in phospholipid liposomal membranes was investigated. The process of lipid peroxidation in liposomes was explored based on the kinetic curves of chemiluminescence reactions in the presence of coumarin C-525. With increasing concentration of aqueous extract from yerba mate in the liposome suspension, a rise in the time period within which the “slow flash” of chemiluminescence reached its maximum value and a decrease in its intensity were observed. This indicates a decrease in the oxidation rate of Fe2+ and a decrease in the rate of lipid radical formation, respectively. Similar results were obtained after addition of the classical radical inhibitors butylhydroxytoluene and trolox to liposomes. However, unlike radical inhibitors, a further increase in the concentration of aqueous extract from mate in the liposomal suspension (more than 2.5 μg of dry plant raw material/ml) was accompanied by a gradual decrease in the time period within which the slow flash of chemiluminescence reached its maximum value, which was typical of the action of iron chelating agents (EDTA and deferoxamine) and caused by a decreased time of Fe2+ oxidation to the critical concentration. It can be supposed that biologically active substances in the composition of aqueous extract from mate exhibit both radical scavenging activity and iron binding ability. The effects of some polyphenolic compounds from the composition of aqueous extracts from mate (quercetin, rutin, chlorogenic acid, and caffeic acid) on Fe2+‑induced liposome chemiluminescence were studied. It has been established that quercetin in a liposome-based model system acted as radical inhibitor. Our study showed that rutin, caffeic acid, and chlorogenic acid exhibit a mixed type of action, they can act as radical scavengers and iron-binding agents. Thus, inhibition of Fe2+-induced lipid peroxidation in biological membranes may be one of the mechanisms for the antioxidant effects of yerba mate observed in vivo.

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Authors and Affiliations

  1. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, 117997, Moscow, Russia

    Yu. O. Teselkin, I. V. Babenkova, A. A. Kochetova & A. N. Osipov

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  1. Yu. O. Teselkin
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  2. I. V. Babenkova
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  3. A. A. Kochetova
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  4. A. N. Osipov
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Correspondence to Yu. O. Teselkin.

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Statement of the welfare of animals. This article does not contain any studies involving animals or human participants performed by any of the authors.

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Translated by D. Timchenko

Abbreviations: BAS, biologically active substance; LP, lipid peroxidation; BHT, butylhydroxytoluene (2,6-di-tert-butyl-4-methylphenol).

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Teselkin, Y.O., Babenkova, I.V., Kochetova, A.A. et al. Inhibitory Effect of Aqueous Extract from Yerba Mate (Ilex paraguariensis) on the Process of Lipid Peroxidation of Liposomal Membranes. BIOPHYSICS 67, 541–548 (2022). https://doi.org/10.1134/S0006350922040194

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