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Frequency Analysis of Oscillations of External Respiration Parameters and Heart Rate in the VLF Range

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Abstract—Very-low-frequency oscillations of respiratory and gas exchange parameters were analyzed in subjects at rest and then compared with the heart rate variability. Time-frequency analysis demonstrated that variability of the main parameters of pulmonary ventilation, gas exchange, and heart rate had an oscillatory nature. The frequency characteristics were shown to coincide in the range of 0.0043–0.016 Hz. Using dynamic visualization, it was found that changes in the Fourier spectra occurred synchronously for the gas exchange parameters and heart rate variability. Cross-correlation analysis revealed a phase shift between fluctuations in heart rate variability and fluctuations in gas exchange rates. Most likely, synchronous slow fluctuations in both the duration of the RR-interval of the ECG and external respiration parameters reflect the functional state of the human cardiorespiratory system. This information opens a new direction in the diagnosis of oxygen transport disorders.

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Funding

This work was supported via a basic fundamental research project of the Russian Academy of Sciences (project IV 35.2.6: AAAA-A21-121011990040-8).

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Authors and Affiliations

  1. Federal Research Center for Information and Computational Technologies, 630090, Novosibirsk, Russia

    V. G. Grishin & V. S. Nikultsev

  2. Federal Research Center of Fundamental and Translational Medicine, 630117, Novosibirsk, Russia

    O. V. Grishin

  3. Novosibirsk State Technical University, 630073, Novosibirsk, Russia

    O. V. Grishin

  4. Research Institute of Neurosciences and Medicine, 630117, Novosibirsk, Russia

    V. V. Gultyaeva, M. I. Zinchenko & D. Yu. Uryumtsev

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  1. V. G. Grishin
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  3. V. S. Nikultsev
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  4. V. V. Gultyaeva
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  5. M. I. Zinchenko
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Correspondence to V. G. Grishin.

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Conflict of interest. The authors declare that they have no conflicts of interest.

Statement of compliance with standards of research involving humans as subjects. The study involved no risk for human health and was conducted in accordance with the ethical standards of the Helsinki Declaration, 2013 update of the 64th General Assembly of the World Medical Association (Fortaleza, Brazil). Informed consent was obtained from all individual participants involved in the study.

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Translated by D. Timchenko

Abbreviations: VLF, very low frequency; OTS, oxygen transport system; BbB method, breath-by-breath evaluation of respiratory function parameters; HRV, heart rate variability; ECG, electrocardiogram; CV, coefficient of variation.

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Grishin, V.G., Grishin, O.V., Nikultsev, V.S. et al. Frequency Analysis of Oscillations of External Respiration Parameters and Heart Rate in the VLF Range. BIOPHYSICS 67, 116–124 (2022). https://doi.org/10.1134/S0006350922010067

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