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The Hepatoprotective Effect of Peroxiredoxin 6 in Ischemia–Reperfusion Kidney Injury

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Abstract

Oxidative stress caused by ischemia–reperfusion kidney injury may play a key role in liver dysfunction. To reduce liver and kidney damage in ischemia–reperfusion kidney injury, an exogenous enzyme antioxidant peroxiredoxin 6 was used, which is able to restore a wide range of hydroperoxides and is a participant in intracellular and intercellular signal transmission. Rats were subjected to ischemic kidney injury for 45 min with simultaneous left-sided nephroectomy and examined after 24 and 48 h of reperfusion. Peroxiredoxin 6 was administered intravenously 15 min before ischemia. Injury to the renal and hepatic tissues was determined by histological methods; in addition, the concentrations of creatinine, urea, alanine aminotransferase and aspartate aminotransferase in the blood were measured to assess the functionality of the organs. Reperfusion led to an increase in the concentrations of creatinine, urea, alanine aminotransferase and aspartate aminotransferase in blood plasma; there was also violation of the architecture of renal nephrons and the development of a pronounced vascular reaction in the liver with foci of degenerative changes. The use of exogenous peroxiredoxin 6 led to a decrease in the damage to the renal and hepatic tissues and normalization of the level of renal and hepatic metabolites. Thus, peroxiredoxin 6 showed both a nephroprotective effect in renal ischemia–reperfusion and reduced morphofunctional damage to distant organs, in particular, the liver.

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ACKNOWLEDGMENTS

The microphotographs presented in this publication were obtained using the equipment of the Optical Microscopy and Spectrophotometry Sector of the CCP of the FIC PSC BI RAS.

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Authors and Affiliations

  1. Institute of Cell Biophysics, Russian Academy of Sciences, 142290, Pushchino, Moscow oblast, Russia

    A. E. Gordeeva & V. I. Novoselov

  2. Pushchino State Natural Science Institute, 142290, Pushchino, Moscow oblast, Russia

    E. A. Kurganova

Authors
  1. A. E. Gordeeva
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  2. E. A. Kurganova
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  3. V. I. Novoselov
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Corresponding author

Correspondence to A. E. Gordeeva.

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Conflict of interest. The authors declare that there is no conflict of interest.

Statement on the welfare of animals. The work with laboratory animals was carried out in accordance with the provisions of the European Convention for the Protection of Vertebrate Animals Used for Experiments and Other Scientific Purposes, the main document regulating the conduct of this study was the Manual for working with laboratory animals of the IBC RAS no. 57 of 30.12.2011.

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Translated by E. Puchkov

Abbreviations: I–R, ischemia–reperfusion; ROS, reactive oxygen species; Prx6, peroxyredoxin 6; ALT, alanine aminotransferase; AST, aspartate aminotransferase.

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Gordeeva, A.E., Kurganova, E.A. & Novoselov, V.I. The Hepatoprotective Effect of Peroxiredoxin 6 in Ischemia–Reperfusion Kidney Injury. BIOPHYSICS 66, 840–847 (2021). https://doi.org/10.1134/S0006350921050067

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  • DOI: https://doi.org/10.1134/S0006350921050067

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