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Inactivation of Bacteria during Stimulation of Sensitizers with High-Power Nanosecond Laser Pulses

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Abstract—The results of a study of photoinactivation of bacteria during stimulation of sensitizers with nanosecond laser pulses with a power density within 1–30 MW/cm2 are presented. The irreversible damage to living cells by shock waves developed during the formation and collapse of vapor bubbles in locally heated microregions of the medium is discussed. The local heating of the medium occurred due to heat release during nonradiative relaxation of high electronic states of sensitizer molecules.

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Funding

This study was supported by the Ministry of Science and Higher Education of the Russian Federation, project no. 3.6358.2017/BCh.

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Authors and Affiliations

  1. Orenburg State University, 460018, Orenburg, Russia

    S. N. Letuta, U. G. Letuta & S. N. Pashkevich

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  1. S. N. Letuta
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  2. U. G. Letuta
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  3. S. N. Pashkevich
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Corresponding author

Correspondence to S. N. Pashkevich.

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The authors declare that they have no conflict of interest. This article does not contain any studies involving animals or human participants performed by any of the authors.

Additional information

Translated by A. Panyushkina

Abbreviations: PS, photosensitizer; HEES, highly excited electronic states; CFU, colony-forming unit.

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Letuta, S.N., Letuta, U.G. & Pashkevich, S.N. Inactivation of Bacteria during Stimulation of Sensitizers with High-Power Nanosecond Laser Pulses. BIOPHYSICS 64, 576–582 (2019). https://doi.org/10.1134/S0006350919040092

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